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Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China
We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene exp...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Centers for Disease Control and Prevention
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084491/ https://www.ncbi.nlm.nih.gov/pubmed/33900193 http://dx.doi.org/10.3201/eid2705.210015 |
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| author | Chu, Daniel K.W. Hui, Kenrie P.Y. Gu, Haogao Ko, Ronald L.W. Krishnan, Pavithra Ng, Daisy Y.M. Liu, Gigi Y.Z. Wan, Carrie K.C. Cheung, Man-Chun Ng, Ka-Chun Nicholls, John M. Tsang, Dominic N.C. Peiris, Malik Chan, Michael C.W. Poon, Leo L.M. |
| author_facet | Chu, Daniel K.W. Hui, Kenrie P.Y. Gu, Haogao Ko, Ronald L.W. Krishnan, Pavithra Ng, Daisy Y.M. Liu, Gigi Y.Z. Wan, Carrie K.C. Cheung, Man-Chun Ng, Ka-Chun Nicholls, John M. Tsang, Dominic N.C. Peiris, Malik Chan, Michael C.W. Poon, Leo L.M. |
| author_sort | Chu, Daniel K.W. |
| collection | PubMed |
| description | We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells. |
| format | Online Article Text |
| id | pubmed-8084491 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Centers for Disease Control and Prevention |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-80844912021-05-11 Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China Chu, Daniel K.W. Hui, Kenrie P.Y. Gu, Haogao Ko, Ronald L.W. Krishnan, Pavithra Ng, Daisy Y.M. Liu, Gigi Y.Z. Wan, Carrie K.C. Cheung, Man-Chun Ng, Ka-Chun Nicholls, John M. Tsang, Dominic N.C. Peiris, Malik Chan, Michael C.W. Poon, Leo L.M. Emerg Infect Dis Dispatch We describe an introduction of clade GH severe acute respiratory syndrome coronavirus 2 causing a fourth wave of coronavirus disease in Hong Kong. The virus has an ORF3a-Q57H mutation, causing truncation of ORF3b. This virus evades induction of cytokine, chemokine, and interferon-stimulated gene expression in primary human respiratory cells. Centers for Disease Control and Prevention 2021-05 /pmc/articles/PMC8084491/ /pubmed/33900193 http://dx.doi.org/10.3201/eid2705.210015 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
| spellingShingle | Dispatch Chu, Daniel K.W. Hui, Kenrie P.Y. Gu, Haogao Ko, Ronald L.W. Krishnan, Pavithra Ng, Daisy Y.M. Liu, Gigi Y.Z. Wan, Carrie K.C. Cheung, Man-Chun Ng, Ka-Chun Nicholls, John M. Tsang, Dominic N.C. Peiris, Malik Chan, Michael C.W. Poon, Leo L.M. Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China |
| title | Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China |
| title_full | Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China |
| title_fullStr | Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China |
| title_full_unstemmed | Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China |
| title_short | Introduction of ORF3a-Q57H SARS-CoV-2 Variant Causing Fourth Epidemic Wave of COVID-19, Hong Kong, China |
| title_sort | introduction of orf3a-q57h sars-cov-2 variant causing fourth epidemic wave of covid-19, hong kong, china |
| topic | Dispatch |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084491/ https://www.ncbi.nlm.nih.gov/pubmed/33900193 http://dx.doi.org/10.3201/eid2705.210015 |
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