Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manif...

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Detalles Bibliográficos
Autores principales: Fintelman-Rodrigues, Natalia, da Silva, Aline P.D., dos Santos, Monique Cristina, Saraiva, Felipe B., Ferreira, Marcelo A., Gesto, João, Rodrigues, Danielle A.S., Vale, André M., de Azevedo, Isaclaudia G., Soares, Vinícius C., Jiang, Hui, Tan, Hongdong, Tschoeke, Diogo A., Sacramento, Carolina Q., Bozza, Fernando A., Morel, Carlos M., Bozza, Patrícia T., Souza, Thiago Moreno L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084520/
https://www.ncbi.nlm.nih.gov/pubmed/33797393
http://dx.doi.org/10.3201/eid2705.204912
Descripción
Sumario:The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.

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