An Fgfr3-activating mutation in immature murine osteoblasts affects the appendicular and craniofacial skeleton

Achondroplasia (ACH), the most common form of dwarfism, is caused by a missense mutation in the gene coding for fibroblast growth factor receptor 3 (FGFR3). The resulting increase in FGFR3 signaling perturbs the proliferation and differentiation of chondrocytes (CCs), alters the process of endochond...

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Detalles Bibliográficos
Autores principales: Biosse Duplan, Martin, Dambroise, Emilie, Estibals, Valentin, Veziers, Joelle, Guicheux, Jérome, Legeai-Mallet, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084574/
https://www.ncbi.nlm.nih.gov/pubmed/33737326
http://dx.doi.org/10.1242/dmm.048272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084574/
https://www.ncbi.nlm.nih.gov/pubmed/33737326
http://dx.doi.org/10.1242/dmm.048272

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