Cargando…

Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway

Low back pain (LBP) has been a wide public health concern worldwide. Among the pathogenic factors, intervertebral disc degeneration (IDD) has been one of the primary contributors to LBP. IDD correlates closely with inflammatory response and oxidative stress, involving a variety of inflammation-relat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Luo, Xi, Huan, Le, Lin, Feng, Kong, Fanqi, Sun, Xiaofei, Li, Fudong, Zhu, Jian, Sun, Jingchuan, Xu, Ximing, Sun, Kaiqiang, Duan, Liwei, Shi, Jiangang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084647/ https://www.ncbi.nlm.nih.gov/pubmed/33968294 http://dx.doi.org/10.1155/2021/5558687

Ejemplares similares

CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-κB Signaling Pathways during Intervertebral Disc Degeneration
por: Sun, Kaiqiang, et al.
Publicado: (2021)

Gamabufotalin Inhibits Osteoclastgenesis and Counteracts Estrogen-Deficient Bone Loss in Mice by Suppressing RANKL-Induced NF-κB and ERK/MAPK Pathways
por: Sun, Kaiqiang, et al.
Publicado: (2021)

Vericiguat Modulates Osteoclast Differentiation and Bone Resorption via a Balance between VASP and NF-κB Pathways
por: Sun, Kaiqiang, et al.
Publicado: (2022)

Arginase II Promotes Intervertebral Disc Degeneration Through Exacerbating Senescence and Apoptosis Caused by Oxidative Stress and Inflammation via the NF-κB Pathway
por: Li, Fudong, et al.
Publicado: (2021)

Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction
por: Sun, Kaiqiang, et al.
Publicado: (2021)

Strontium Ranelate Ameliorates Intervertebral Disc Degeneration via Regulating TGF-β1/NF-κB Axis
por: Sun, Ruping, et al.
Publicado: (2023)

S100A9 induces nucleus pulposus cell degeneration through activation of the NF‐κB signaling pathway
por: Guo, Song, et al.
Publicado: (2021)

NF‐κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration
por: Zhang, Guang‐Zhi, et al.
Publicado: (2021)

Autophagy attenuates the catabolic effect during inflammatory conditions in nucleus pulposus cells, as sustained by NF-κB and JNK inhibition
por: XU, KANG, et al.
Publicado: (2015)

Moracin attenuates LPS-induced inflammation in nucleus pulposus cells via Nrf2/HO-1 and NF-κB/TGF-β pathway
por: Gu, Ronghe, et al.
Publicado: (2019)

PD-L1 Improves Motor Function and Alleviates Neuropathic Pain in Male Mice After Spinal Cord Injury by Inhibiting MAPK Pathway
por: Kong, Fanqi, et al.
Publicado: (2021)

Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-κB-NLRP3 axis
por: Lu, Peng, et al.
Publicado: (2023)

Comparison of Surgical Results of the Bridge Crane Technique Versus Laminectomy for the Treatment of Thoracic Myelopathy Caused by Ossification of the Ligamentum Flavum
por: Sun, Kaiqiang, et al.
Publicado: (2021)

Impact of NF-κB pathway on the apoptosis-inflammation-autophagy crosstalk in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2019)

LIPUS inhibits inflammation and catabolism through the NF‐κB pathway in human degenerative nucleus pulposus cells
por: Yi, Weiwei, et al.
Publicado: (2021)

The Gantry Crane Technique: A Novel Technique for Treating Severe Thoracic Spinal Stenosis and Myelopathy Caused by Ossification of the Ligamentum Flavum and Preliminary Clinical Results
por: Zhu, Jian, et al.
Publicado: (2021)

Mechanical loading mediates human nucleus pulposus cell viability and extracellular matrix metabolism by activating of NF-κB
por: Zhang, Kai, et al.
Publicado: (2019)

Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration
por: Wang, Ruihong, et al.
Publicado: (2021)

The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3
por: Zhu, Jian, et al.
Publicado: (2023)

Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling
por: Chen, Zhiqian, et al.
Publicado: (2021)

Effect of ulinastatin on growth inhibition, apoptosis of breast carcinoma cells is related to a decrease in signal conduction of JNk-2 and NF-κB
por: Wang, Hong, et al.
Publicado: (2012)

Effects of the NF-κB/p53 signaling pathway on intervertebral disc nucleus pulposus degeneration
por: Zhang, Litao, et al.
Publicado: (2020)

IL-1β increases asporin expression via the NF-κB p65 pathway in nucleus pulposus cells during intervertebral disc degeneration
por: Wang, Shengjie, et al.
Publicado: (2017)

Overexpression of LMP-1 Decreases Apoptosis in Human Nucleus Pulposus Cells via Suppressing the NF-κB Signaling Pathway
por: Liu, Yuan, et al.
Publicado: (2020)

Placement of Titanium Mesh in Hybrid Decompression Surgery to Avoid Graft Subsidence in Treatment of Three-Level Cervical Spondylotic Myelopathy: Cephalad or Caudal?
por: Sun, Kaiqiang, et al.
Publicado: (2018)

Inhibition of the Notch1 Pathway Promotes the Effects of Nucleus Pulposus Cell-Derived Exosomes on the Differentiation of Mesenchymal Stem Cells into Nucleus Pulposus-Like Cells in Rats
por: Lan, Wei-ren, et al.
Publicado: (2019)

Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression
por: Jiang, Yanhai, et al.
Publicado: (2018)

Osteogenic protein-1 inhibits nucleus pulposus cell apoptosis through regulating the NF-κB/ROS pathway in an inflammation environment
por: Yu, Wei, et al.
Publicado: (2018)

SDF-1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF-κB pathway
por: LIU, ZONGCHAO, et al.
Publicado: (2016)

Follistatin-like protein 1 promotes inflammatory reactions in nucleus pulposus cells by interacting with the MAPK and NFκB signaling pathways
por: Liu, Yi, et al.
Publicado: (2017)

Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells
por: Cao, Xiankun, et al.
Publicado: (2022)

Development and Validation of a Novel Nomogram to Predict the Risk of Intervertebral Disc Degeneration
por: Li, Fudong, et al.
Publicado: (2022)

Hydrogen sulfide regulates autophagy in nucleus pulposus cells under hypoxia
por: Yue, Lei, et al.
Publicado: (2021)

The Effect of Diabetes Mellitus on the Neurological Function of Patients with Cervical Spondylotic Myelopathy
por: Jiang, Jialin, et al.
Publicado: (2022)

Metformin protects against apoptosis and senescence in nucleus pulposus cells and ameliorates disc degeneration in vivo
por: Chen, Deheng, et al.
Publicado: (2016)

Collagen type II is downregulated in the degenerative nucleus pulposus and contributes to the degeneration and apoptosis of human nucleus pulposus cells
por: Lian, Chengjie, et al.
Publicado: (2017)

The enigma that is the nucleus pulposus cell: the search goes on
por: Erwin, W Mark
Publicado: (2010)

Cell sources proposed for nucleus pulposus regeneration
por: Williams, Rebecca J., et al.
Publicado: (2021)

Alterations of bovine nucleus pulposus cells with aging
por: Molinos, Maria, et al.
Publicado: (2023)

Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus
por: Shan, Liang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q64fg49bkgqh6jm0ac4ljuo4mt