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Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients

PURPOSE: To investigate correlations between myositis-specific autoantibodies (MSA) or myositis-associated antibodies (MAA) and clinical features, thereby demonstrating the utility of clinicoserologic classification in idiopathic inflammatory myopathies (IIM) patients. MATERIALS AND METHODS: We cond...

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Autores principales: Chung, Sang Wan, Yoo, In Seol, Kim, Jinhyun, Kang, Seong Wook, Kwon, Mihye, Joung, Chung-Il, Choi, In Ah, Chang, Sung Hae, Kang, Mi Il, Hong, Seung-Jae, Lee, Yeon-Ah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084694/
https://www.ncbi.nlm.nih.gov/pubmed/33908213
http://dx.doi.org/10.3349/ymj.2021.62.5.424
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author Chung, Sang Wan
Yoo, In Seol
Kim, Jinhyun
Kang, Seong Wook
Kwon, Mihye
Joung, Chung-Il
Choi, In Ah
Chang, Sung Hae
Kang, Mi Il
Hong, Seung-Jae
Lee, Yeon-Ah
author_facet Chung, Sang Wan
Yoo, In Seol
Kim, Jinhyun
Kang, Seong Wook
Kwon, Mihye
Joung, Chung-Il
Choi, In Ah
Chang, Sung Hae
Kang, Mi Il
Hong, Seung-Jae
Lee, Yeon-Ah
author_sort Chung, Sang Wan
collection PubMed
description PURPOSE: To investigate correlations between myositis-specific autoantibodies (MSA) or myositis-associated antibodies (MAA) and clinical features, thereby demonstrating the utility of clinicoserologic classification in idiopathic inflammatory myopathies (IIM) patients. MATERIALS AND METHODS: We conducted a multicenter study of 108 adult patients (age ≥18 years) who were diagnosed with IIM by Peter and Bohan criteria or 2004 European Neuromuscular Centre (ENMC) criteria. Clinical data were obtained by medical record review. Immunoblot assay with Euroline strip (EUROIMMUN, Germany) was performed using the sera of dermatomyositis (DM, n=56), polymyositis (PM, n=45), amyopathic DM (n=5), DM sine dermatitis (n=1), and immune mediated necrotizing myopathy (n=1) patients. Patients were classified based on two classifications: 2017 EULAR/ACR and novel clinicoserologic classification. RESULTS: According to 2017 EULAR/ACR criteria, DM and PM were the most and the second most frequent entities. Overlap myositis was the major entity of IIM, and the frequency of PM was significantly lower when applying clinicoserologic classification criteria. Sixty-nine (63.9%) patients had one or more MSA, and 61 (56.5%) patients had one or more MAA. Interstitial lung disease was closely associated with anti-MDA5 and anti-ARS, and DM-specific skin lesions were frequently observed in patients with anti-TIF1γ, anti-SRP, and anti-MDA5. CONCLUSION: The clinicoserologic criteria based on MSA/MAA positivity could reflect more precise clinical features of IIM. Establishment of a laboratory system routinely available to screen for MSA/MAA status will be beneficial to provide precise diagnosis and proper management of IIM patients.
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spelling pubmed-80846942021-05-11 Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients Chung, Sang Wan Yoo, In Seol Kim, Jinhyun Kang, Seong Wook Kwon, Mihye Joung, Chung-Il Choi, In Ah Chang, Sung Hae Kang, Mi Il Hong, Seung-Jae Lee, Yeon-Ah Yonsei Med J Original Article PURPOSE: To investigate correlations between myositis-specific autoantibodies (MSA) or myositis-associated antibodies (MAA) and clinical features, thereby demonstrating the utility of clinicoserologic classification in idiopathic inflammatory myopathies (IIM) patients. MATERIALS AND METHODS: We conducted a multicenter study of 108 adult patients (age ≥18 years) who were diagnosed with IIM by Peter and Bohan criteria or 2004 European Neuromuscular Centre (ENMC) criteria. Clinical data were obtained by medical record review. Immunoblot assay with Euroline strip (EUROIMMUN, Germany) was performed using the sera of dermatomyositis (DM, n=56), polymyositis (PM, n=45), amyopathic DM (n=5), DM sine dermatitis (n=1), and immune mediated necrotizing myopathy (n=1) patients. Patients were classified based on two classifications: 2017 EULAR/ACR and novel clinicoserologic classification. RESULTS: According to 2017 EULAR/ACR criteria, DM and PM were the most and the second most frequent entities. Overlap myositis was the major entity of IIM, and the frequency of PM was significantly lower when applying clinicoserologic classification criteria. Sixty-nine (63.9%) patients had one or more MSA, and 61 (56.5%) patients had one or more MAA. Interstitial lung disease was closely associated with anti-MDA5 and anti-ARS, and DM-specific skin lesions were frequently observed in patients with anti-TIF1γ, anti-SRP, and anti-MDA5. CONCLUSION: The clinicoserologic criteria based on MSA/MAA positivity could reflect more precise clinical features of IIM. Establishment of a laboratory system routinely available to screen for MSA/MAA status will be beneficial to provide precise diagnosis and proper management of IIM patients. Yonsei University College of Medicine 2021-05-01 2021-04-20 /pmc/articles/PMC8084694/ /pubmed/33908213 http://dx.doi.org/10.3349/ymj.2021.62.5.424 Text en © Copyright: Yonsei University College of Medicine 2021 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chung, Sang Wan
Yoo, In Seol
Kim, Jinhyun
Kang, Seong Wook
Kwon, Mihye
Joung, Chung-Il
Choi, In Ah
Chang, Sung Hae
Kang, Mi Il
Hong, Seung-Jae
Lee, Yeon-Ah
Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
title Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
title_full Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
title_fullStr Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
title_full_unstemmed Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
title_short Comparison of the 2017 EULAR/ACR Criteria with Clinicoserologic Criteria for the Classification of Idiopathic Inflammatory Myopathies in Korean Patients
title_sort comparison of the 2017 eular/acr criteria with clinicoserologic criteria for the classification of idiopathic inflammatory myopathies in korean patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084694/
https://www.ncbi.nlm.nih.gov/pubmed/33908213
http://dx.doi.org/10.3349/ymj.2021.62.5.424
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