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Roles of Type I and III Interferons in COVID-19

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cel...

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Autores principales: Choi, Hojun, Shin, Eui-Cheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084697/
https://www.ncbi.nlm.nih.gov/pubmed/33908208
http://dx.doi.org/10.3349/ymj.2021.62.5.381
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author Choi, Hojun
Shin, Eui-Cheol
author_facet Choi, Hojun
Shin, Eui-Cheol
author_sort Choi, Hojun
collection PubMed
description Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be investigated further. In the absence of a highly efficacious antiviral drug, clinical studies have evaluated recombinant type I and III IFNs, as they have been successfully used for the treatment of infections caused by two other epidemic coronaviruses, SARS-CoV-1 and Middle East respiratory syndrome (MERS)-CoV. In this review, we describe the strategies by which SARS-CoV-2 evades IFN responses and the dysregulation of host IFN responses in COVID-19 patients. In addition, we discuss the therapeutic potential of type I and III IFNs in COVID-19.
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spelling pubmed-80846972021-05-11 Roles of Type I and III Interferons in COVID-19 Choi, Hojun Shin, Eui-Cheol Yonsei Med J Review Article Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Type I and III interferon (IFN) responses act as the first line of defense against viral infection and are activated by the recognition of viruses by infected cells and innate immune cells. Dysregulation of host IFN responses has been known to be associated with severe disease progression in COVID-19 patients. However, the reported results are controversial and the roles of IFN responses in COVID-19 need to be investigated further. In the absence of a highly efficacious antiviral drug, clinical studies have evaluated recombinant type I and III IFNs, as they have been successfully used for the treatment of infections caused by two other epidemic coronaviruses, SARS-CoV-1 and Middle East respiratory syndrome (MERS)-CoV. In this review, we describe the strategies by which SARS-CoV-2 evades IFN responses and the dysregulation of host IFN responses in COVID-19 patients. In addition, we discuss the therapeutic potential of type I and III IFNs in COVID-19. Yonsei University College of Medicine 2021-05-01 2021-04-20 /pmc/articles/PMC8084697/ /pubmed/33908208 http://dx.doi.org/10.3349/ymj.2021.62.5.381 Text en © Copyright: Yonsei University College of Medicine 2021 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Choi, Hojun
Shin, Eui-Cheol
Roles of Type I and III Interferons in COVID-19
title Roles of Type I and III Interferons in COVID-19
title_full Roles of Type I and III Interferons in COVID-19
title_fullStr Roles of Type I and III Interferons in COVID-19
title_full_unstemmed Roles of Type I and III Interferons in COVID-19
title_short Roles of Type I and III Interferons in COVID-19
title_sort roles of type i and iii interferons in covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084697/
https://www.ncbi.nlm.nih.gov/pubmed/33908208
http://dx.doi.org/10.3349/ymj.2021.62.5.381
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