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Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea
PURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We inve...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Yonsei University College of Medicine
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084702/ https://www.ncbi.nlm.nih.gov/pubmed/33908212 http://dx.doi.org/10.3349/ymj.2021.62.5.417 |
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author | Kim, Beong Ki Kim, Sua Kim, Chi Young Kim, Yu Jin Lee, Seung Heon Cha, Jae Hyung Kim, Je Hyeong |
author_facet | Kim, Beong Ki Kim, Sua Kim, Chi Young Kim, Yu Jin Lee, Seung Heon Cha, Jae Hyung Kim, Je Hyeong |
author_sort | Kim, Beong Ki |
collection | PubMed |
description | PURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population. MATERIALS AND METHODS: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single university-affiliated hospital in Korea from September 1, 2018, to August 31, 2019. LIPS at the time of ICU admission and the development of ARDS were evaluated. RESULTS: Of the 548 enrolled patients, 33 (6.0%) fulfilled the Berlin ARDS definition. The LIPS for non-ARDS and ARDS groups were 4.96±3.05 and 8.53±2.45, respectively (p<0.001); it was significantly associated with ARDS development (odds ratio 1.48, 95% confidence interval, 1.29–1.69; p<0.001). LIPS >6 predicted the development of ARDS with a sensitivity of 84.8% and a specificity of 67.2% [area under the curve (AUC)=0.82]. A modified LIPS model adjusted for age and severity at ICU admission predicted ICU mortality in patients with ARDS (AUC=0.80), but not in those without ARDS (AUC=0.54). CONCLUSION: LIPS predicted the development of ARDS as diagnosed by the Berlin definition in the Korean population. LIPS provides useful information for managing patients with ARDS. |
format | Online Article Text |
id | pubmed-8084702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Yonsei University College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-80847022021-05-11 Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea Kim, Beong Ki Kim, Sua Kim, Chi Young Kim, Yu Jin Lee, Seung Heon Cha, Jae Hyung Kim, Je Hyeong Yonsei Med J Original Article PURPOSE: Early recognition and therapeutic intervention are important in patients at high risk of acute respiratory distress syndrome (ARDS). The lung injury prediction score (LIPS) has been used to predict ARDS development; however, it was developed based on the previous definition of ARDS. We investigated the predictive role of LIPS in ARDS development according to its Berlin definition in the Korean population. MATERIALS AND METHODS: This was a retrospective study that enrolled adult patients admitted to the intensive care unit (ICU) at a single university-affiliated hospital in Korea from September 1, 2018, to August 31, 2019. LIPS at the time of ICU admission and the development of ARDS were evaluated. RESULTS: Of the 548 enrolled patients, 33 (6.0%) fulfilled the Berlin ARDS definition. The LIPS for non-ARDS and ARDS groups were 4.96±3.05 and 8.53±2.45, respectively (p<0.001); it was significantly associated with ARDS development (odds ratio 1.48, 95% confidence interval, 1.29–1.69; p<0.001). LIPS >6 predicted the development of ARDS with a sensitivity of 84.8% and a specificity of 67.2% [area under the curve (AUC)=0.82]. A modified LIPS model adjusted for age and severity at ICU admission predicted ICU mortality in patients with ARDS (AUC=0.80), but not in those without ARDS (AUC=0.54). CONCLUSION: LIPS predicted the development of ARDS as diagnosed by the Berlin definition in the Korean population. LIPS provides useful information for managing patients with ARDS. Yonsei University College of Medicine 2021-05-01 2021-04-20 /pmc/articles/PMC8084702/ /pubmed/33908212 http://dx.doi.org/10.3349/ymj.2021.62.5.417 Text en © Copyright: Yonsei University College of Medicine 2021 https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Beong Ki Kim, Sua Kim, Chi Young Kim, Yu Jin Lee, Seung Heon Cha, Jae Hyung Kim, Je Hyeong Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea |
title | Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea |
title_full | Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea |
title_fullStr | Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea |
title_full_unstemmed | Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea |
title_short | Predictive Role of Lung Injury Prediction Score in the Development of Acute Respiratory Distress Syndrome in Korea |
title_sort | predictive role of lung injury prediction score in the development of acute respiratory distress syndrome in korea |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084702/ https://www.ncbi.nlm.nih.gov/pubmed/33908212 http://dx.doi.org/10.3349/ymj.2021.62.5.417 |
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