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Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis

PURPOSE: Unilateral coronal synostosis (UCS) results in an asymmetrical skull, including shallow and asymmetrical orbits, associated with reduced orbital volume and high prevalences of ophthalmic sequelae. Aim is to link orbital volumes in patients with UCS to severity according to UCSQ (Utrecht Cra...

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Autores principales: Kronig, Sophia A. J., Kronig, Otto D. M., Zurek, Marcel, Van Adrichem, Léon N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084761/
https://www.ncbi.nlm.nih.gov/pubmed/33566143
http://dx.doi.org/10.1007/s00381-021-05065-3
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author Kronig, Sophia A. J.
Kronig, Otto D. M.
Zurek, Marcel
Van Adrichem, Léon N. A.
author_facet Kronig, Sophia A. J.
Kronig, Otto D. M.
Zurek, Marcel
Van Adrichem, Léon N. A.
author_sort Kronig, Sophia A. J.
collection PubMed
description PURPOSE: Unilateral coronal synostosis (UCS) results in an asymmetrical skull, including shallow and asymmetrical orbits, associated with reduced orbital volume and high prevalences of ophthalmic sequelae. Aim is to link orbital volumes in patients with UCS to severity according to UCSQ (Utrecht Cranial Shape Quantifier) and presence of ophthalmic sequelae. METHODS: We included preoperative patients with UCS (≤ 18 months). Orbital volume was measured on CT scans by manual segmentation (Mimics software (Materialise, Leuven, Belgium)), and severity of UCS was determined by UCSQ. Orbital volume of affected side was compared to unaffected side using Wilcoxon signed rank test. Orbital volume ratio was calculated (affected/unaffected volume) and compared to the category of UCSQ by Kruskal-Wallis test. Opthalmic sequelae were noted. RESULTS: We included 19 patients (mean age 7 months). Orbital volume on affected side was significantly lower (p = 0.001), mean orbital volume ratio was 0.93 (SD 0.03). No significant differences in group means of orbital volume ratio between different levels of severity of UCSQ were found (Kruskal-Wallis H (2) = 0.873; p > 0.05). Ophthalmic sequelae were found in 3 patients; one had adduction impairment and strabismus (mild UCS), one had astigmatism (moderate UCS), and one had abduction impairment (on both ipsi- and contralateral side) and vertical strabismus (severe UCS). CONCLUSION: No association between orbital volume ratio and severity of UCS was found. Side-to-side asymmetry in orbital volume was noted. No association between either preoperative orbital volume ratio or severity of UCS and the presence of preoperative ophthalmic sequelae was found.
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spelling pubmed-80847612021-05-05 Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis Kronig, Sophia A. J. Kronig, Otto D. M. Zurek, Marcel Van Adrichem, Léon N. A. Childs Nerv Syst Original Article PURPOSE: Unilateral coronal synostosis (UCS) results in an asymmetrical skull, including shallow and asymmetrical orbits, associated with reduced orbital volume and high prevalences of ophthalmic sequelae. Aim is to link orbital volumes in patients with UCS to severity according to UCSQ (Utrecht Cranial Shape Quantifier) and presence of ophthalmic sequelae. METHODS: We included preoperative patients with UCS (≤ 18 months). Orbital volume was measured on CT scans by manual segmentation (Mimics software (Materialise, Leuven, Belgium)), and severity of UCS was determined by UCSQ. Orbital volume of affected side was compared to unaffected side using Wilcoxon signed rank test. Orbital volume ratio was calculated (affected/unaffected volume) and compared to the category of UCSQ by Kruskal-Wallis test. Opthalmic sequelae were noted. RESULTS: We included 19 patients (mean age 7 months). Orbital volume on affected side was significantly lower (p = 0.001), mean orbital volume ratio was 0.93 (SD 0.03). No significant differences in group means of orbital volume ratio between different levels of severity of UCSQ were found (Kruskal-Wallis H (2) = 0.873; p > 0.05). Ophthalmic sequelae were found in 3 patients; one had adduction impairment and strabismus (mild UCS), one had astigmatism (moderate UCS), and one had abduction impairment (on both ipsi- and contralateral side) and vertical strabismus (severe UCS). CONCLUSION: No association between orbital volume ratio and severity of UCS was found. Side-to-side asymmetry in orbital volume was noted. No association between either preoperative orbital volume ratio or severity of UCS and the presence of preoperative ophthalmic sequelae was found. Springer Berlin Heidelberg 2021-02-10 2021 /pmc/articles/PMC8084761/ /pubmed/33566143 http://dx.doi.org/10.1007/s00381-021-05065-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Kronig, Sophia A. J.
Kronig, Otto D. M.
Zurek, Marcel
Van Adrichem, Léon N. A.
Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
title Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
title_full Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
title_fullStr Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
title_full_unstemmed Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
title_short Orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
title_sort orbital volume, ophthalmic sequelae and severity in unilateral coronal synostosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084761/
https://www.ncbi.nlm.nih.gov/pubmed/33566143
http://dx.doi.org/10.1007/s00381-021-05065-3
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