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Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy
BACKGROUND: An association between bladder-bowel dysfunction (BBD) and urinary tract infection (UTI) is well-known. However, a question less explored is whether children with UTI early in life also have increased prevalence of BBD after they are toilet-trained. In this study, consecutively selected...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084797/ https://www.ncbi.nlm.nih.gov/pubmed/33274398 http://dx.doi.org/10.1007/s00467-020-04853-4 |
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author | Sjöström, Sofia Sillén, Ulla Bachelard, Marc Johansson, Ewa Brandström, Per Hellström, Anna-Lena Abrahamsson, Kate |
author_facet | Sjöström, Sofia Sillén, Ulla Bachelard, Marc Johansson, Ewa Brandström, Per Hellström, Anna-Lena Abrahamsson, Kate |
author_sort | Sjöström, Sofia |
collection | PubMed |
description | BACKGROUND: An association between bladder-bowel dysfunction (BBD) and urinary tract infection (UTI) is well-known. However, a question less explored is whether children with UTI early in life also have increased prevalence of BBD after they are toilet-trained. In this study, consecutively selected children with pyelonephritis during their first year of life were assessed for BBD at pre-school age. METHODS: Ninety-two children (51 boys) hospitalized due to pyelonephritis during their first year of life were assessed for BBD at median age 5.4 years. A validated BBD questionnaire, along with urine flow and residual volume measurements, was used for diagnosing BBD. During follow-up, the group was well-characterized regarding renal status, vesicoureteral reflux (VUR), and recurrent UTI. RESULTS: BBD was diagnosed in 35/92 (38%), of which the majority was sub-diagnosed with dysfunctional voiding (DV). There was a strong association between BBD and recurrent UTI during follow-up (p < 0.0001), but only a slight association with VUR status at presentation. Nevertheless, in the group with both BBD and VUR, recurrent UTI was four times higher (12/13, 92%) than in children who had neither VUR nor BBD (23%), (p = 0.0008). BBD was also associated with kidney damage (p = 0.017). CONCLUSION: In children with pyelonephritis during the first year of life, 38% had BBD at pre-school age, regardless of whether they had VUR or not. The study shows an important association between BBD and recurrent UTI, so an assessment of BBD is therefore recommended for pre-school children with UTI, especially when they have history of pyelonephritis during infancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-020-04853-4. |
format | Online Article Text |
id | pubmed-8084797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-80847972021-05-05 Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy Sjöström, Sofia Sillén, Ulla Bachelard, Marc Johansson, Ewa Brandström, Per Hellström, Anna-Lena Abrahamsson, Kate Pediatr Nephrol Original Article BACKGROUND: An association between bladder-bowel dysfunction (BBD) and urinary tract infection (UTI) is well-known. However, a question less explored is whether children with UTI early in life also have increased prevalence of BBD after they are toilet-trained. In this study, consecutively selected children with pyelonephritis during their first year of life were assessed for BBD at pre-school age. METHODS: Ninety-two children (51 boys) hospitalized due to pyelonephritis during their first year of life were assessed for BBD at median age 5.4 years. A validated BBD questionnaire, along with urine flow and residual volume measurements, was used for diagnosing BBD. During follow-up, the group was well-characterized regarding renal status, vesicoureteral reflux (VUR), and recurrent UTI. RESULTS: BBD was diagnosed in 35/92 (38%), of which the majority was sub-diagnosed with dysfunctional voiding (DV). There was a strong association between BBD and recurrent UTI during follow-up (p < 0.0001), but only a slight association with VUR status at presentation. Nevertheless, in the group with both BBD and VUR, recurrent UTI was four times higher (12/13, 92%) than in children who had neither VUR nor BBD (23%), (p = 0.0008). BBD was also associated with kidney damage (p = 0.017). CONCLUSION: In children with pyelonephritis during the first year of life, 38% had BBD at pre-school age, regardless of whether they had VUR or not. The study shows an important association between BBD and recurrent UTI, so an assessment of BBD is therefore recommended for pre-school children with UTI, especially when they have history of pyelonephritis during infancy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00467-020-04853-4. Springer Berlin Heidelberg 2020-12-04 2021 /pmc/articles/PMC8084797/ /pubmed/33274398 http://dx.doi.org/10.1007/s00467-020-04853-4 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Sjöström, Sofia Sillén, Ulla Bachelard, Marc Johansson, Ewa Brandström, Per Hellström, Anna-Lena Abrahamsson, Kate Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
title | Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
title_full | Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
title_fullStr | Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
title_full_unstemmed | Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
title_short | Bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
title_sort | bladder/bowel dysfunction in pre-school children following febrile urinary tract infection in infancy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084797/ https://www.ncbi.nlm.nih.gov/pubmed/33274398 http://dx.doi.org/10.1007/s00467-020-04853-4 |
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