Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone...

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Autores principales: Barnsley, J., Buckland, G., Chan, P. E., Ong, A., Ramos, A. S., Baxter, M., Laskou, F., Dennison, E. M., Cooper, C., Patel, Harnish P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084810/
https://www.ncbi.nlm.nih.gov/pubmed/33742387
http://dx.doi.org/10.1007/s40520-021-01817-y
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author Barnsley, J.
Buckland, G.
Chan, P. E.
Ong, A.
Ramos, A. S.
Baxter, M.
Laskou, F.
Dennison, E. M.
Cooper, C.
Patel, Harnish P.
author_facet Barnsley, J.
Buckland, G.
Chan, P. E.
Ong, A.
Ramos, A. S.
Baxter, M.
Laskou, F.
Dennison, E. M.
Cooper, C.
Patel, Harnish P.
author_sort Barnsley, J.
collection PubMed
description Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-021-01817-y.
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spelling pubmed-80848102021-05-05 Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people Barnsley, J. Buckland, G. Chan, P. E. Ong, A. Ramos, A. S. Baxter, M. Laskou, F. Dennison, E. M. Cooper, C. Patel, Harnish P. Aging Clin Exp Res Review Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40520-021-01817-y. Springer International Publishing 2021-03-20 2021 /pmc/articles/PMC8084810/ /pubmed/33742387 http://dx.doi.org/10.1007/s40520-021-01817-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Barnsley, J.
Buckland, G.
Chan, P. E.
Ong, A.
Ramos, A. S.
Baxter, M.
Laskou, F.
Dennison, E. M.
Cooper, C.
Patel, Harnish P.
Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
title Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
title_full Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
title_fullStr Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
title_full_unstemmed Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
title_short Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
title_sort pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084810/
https://www.ncbi.nlm.nih.gov/pubmed/33742387
http://dx.doi.org/10.1007/s40520-021-01817-y
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