Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing

Mycoplasma hominis is a common colonizer of the lower genitourinary tract. Although its clinical relevance for causing urogenital infections in immunocompetent individuals is controversial, this bacterium has been involved in severe invasive infections in allograft recipients. In this report, we des...

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Autores principales: Hinić, V., Seth-Smith, H. M. B., Damm, S., Amico, P., Khanna, N., Egli, A., Bättig, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084823/
https://www.ncbi.nlm.nih.gov/pubmed/33367958
http://dx.doi.org/10.1007/s10096-020-04116-y
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author Hinić, V.
Seth-Smith, H. M. B.
Damm, S.
Amico, P.
Khanna, N.
Egli, A.
Bättig, V.
author_facet Hinić, V.
Seth-Smith, H. M. B.
Damm, S.
Amico, P.
Khanna, N.
Egli, A.
Bättig, V.
author_sort Hinić, V.
collection PubMed
description Mycoplasma hominis is a common colonizer of the lower genitourinary tract. Although its clinical relevance for causing urogenital infections in immunocompetent individuals is controversial, this bacterium has been involved in severe invasive infections in allograft recipients. In this report, we describe two cases of M. hominis infection in two young renal transplant recipients within the first month post-transplant. Although at first no epidemiological link between the two cases had been suspected, whole-genome sequencing (WGS) analysis showed that both isolates were identical, highly suggestive of an origin with the common organ donor. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04116-y.
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spelling pubmed-80848232021-05-05 Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing Hinić, V. Seth-Smith, H. M. B. Damm, S. Amico, P. Khanna, N. Egli, A. Bättig, V. Eur J Clin Microbiol Infect Dis Brief Report Mycoplasma hominis is a common colonizer of the lower genitourinary tract. Although its clinical relevance for causing urogenital infections in immunocompetent individuals is controversial, this bacterium has been involved in severe invasive infections in allograft recipients. In this report, we describe two cases of M. hominis infection in two young renal transplant recipients within the first month post-transplant. Although at first no epidemiological link between the two cases had been suspected, whole-genome sequencing (WGS) analysis showed that both isolates were identical, highly suggestive of an origin with the common organ donor. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-020-04116-y. Springer Berlin Heidelberg 2020-12-23 2021 /pmc/articles/PMC8084823/ /pubmed/33367958 http://dx.doi.org/10.1007/s10096-020-04116-y Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Hinić, V.
Seth-Smith, H. M. B.
Damm, S.
Amico, P.
Khanna, N.
Egli, A.
Bättig, V.
Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
title Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
title_full Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
title_fullStr Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
title_full_unstemmed Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
title_short Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
title_sort unexpected mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084823/
https://www.ncbi.nlm.nih.gov/pubmed/33367958
http://dx.doi.org/10.1007/s10096-020-04116-y
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