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Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI

BACKGROUND: Stereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true progression by weeks or months. METHODS: Pat...

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Autores principales: Lee, Casey Y., Soliman, Hany, Bragagnolo, Nadia D., Sahgal, Arjun, Geraghty, Benjamin J., Chen, Albert P., Endre, Ruby, Perks, William J., Detsky, Jay S., Leung, Eric, Chan, Michael, Heyn, Chris, Cunningham, Charles H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084843/
https://www.ncbi.nlm.nih.gov/pubmed/33740165
http://dx.doi.org/10.1007/s11060-021-03725-7
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author Lee, Casey Y.
Soliman, Hany
Bragagnolo, Nadia D.
Sahgal, Arjun
Geraghty, Benjamin J.
Chen, Albert P.
Endre, Ruby
Perks, William J.
Detsky, Jay S.
Leung, Eric
Chan, Michael
Heyn, Chris
Cunningham, Charles H.
author_facet Lee, Casey Y.
Soliman, Hany
Bragagnolo, Nadia D.
Sahgal, Arjun
Geraghty, Benjamin J.
Chen, Albert P.
Endre, Ruby
Perks, William J.
Detsky, Jay S.
Leung, Eric
Chan, Michael
Heyn, Chris
Cunningham, Charles H.
author_sort Lee, Casey Y.
collection PubMed
description BACKGROUND: Stereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true progression by weeks or months. METHODS: Patients with intracranial metastases (N = 11) were scanned using hyperpolarized [Formula: see text] C MRI prior to treatment with stereotactic radiosurgery (SRS). The status of each lesion was then recorded at six months post-treatment follow-up (or at the time of death). RESULTS: The positive predictive value of [Formula: see text] C-lactate signal, measured pre-treatment, for prediction of progression of intracranial metastases at six months post-treatment with SRS was 0.8 [Formula: see text] , and the AUC from an ROC analysis was 0.77 [Formula: see text] . The distribution of [Formula: see text] C-lactate z-scores was different for intracranial metastases from different primary cancer types (F = 2.46, [Formula: see text] ). CONCLUSIONS: Hyperpolarized [Formula: see text] C imaging has potential as a method for improving outcomes for patients with intracranial metastases, by identifying patients at high risk of treatment failure with SRS and considering other therapeutic options such as surgery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11060-021-03725-7.
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spelling pubmed-80848432021-05-05 Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI Lee, Casey Y. Soliman, Hany Bragagnolo, Nadia D. Sahgal, Arjun Geraghty, Benjamin J. Chen, Albert P. Endre, Ruby Perks, William J. Detsky, Jay S. Leung, Eric Chan, Michael Heyn, Chris Cunningham, Charles H. J Neurooncol Clinical Study BACKGROUND: Stereotactic radiosurgery (SRS) is used to manage intracranial metastases in a significant fraction of patients. Local progression after SRS can often only be detected with increased volume of enhancement on serial MRI scans which may lag true progression by weeks or months. METHODS: Patients with intracranial metastases (N = 11) were scanned using hyperpolarized [Formula: see text] C MRI prior to treatment with stereotactic radiosurgery (SRS). The status of each lesion was then recorded at six months post-treatment follow-up (or at the time of death). RESULTS: The positive predictive value of [Formula: see text] C-lactate signal, measured pre-treatment, for prediction of progression of intracranial metastases at six months post-treatment with SRS was 0.8 [Formula: see text] , and the AUC from an ROC analysis was 0.77 [Formula: see text] . The distribution of [Formula: see text] C-lactate z-scores was different for intracranial metastases from different primary cancer types (F = 2.46, [Formula: see text] ). CONCLUSIONS: Hyperpolarized [Formula: see text] C imaging has potential as a method for improving outcomes for patients with intracranial metastases, by identifying patients at high risk of treatment failure with SRS and considering other therapeutic options such as surgery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s11060-021-03725-7. Springer US 2021-03-19 2021 /pmc/articles/PMC8084843/ /pubmed/33740165 http://dx.doi.org/10.1007/s11060-021-03725-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Clinical Study
Lee, Casey Y.
Soliman, Hany
Bragagnolo, Nadia D.
Sahgal, Arjun
Geraghty, Benjamin J.
Chen, Albert P.
Endre, Ruby
Perks, William J.
Detsky, Jay S.
Leung, Eric
Chan, Michael
Heyn, Chris
Cunningham, Charles H.
Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI
title Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI
title_full Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI
title_fullStr Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI
title_full_unstemmed Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI
title_short Predicting response to radiotherapy of intracranial metastases with hyperpolarized [Formula: see text] C MRI
title_sort predicting response to radiotherapy of intracranial metastases with hyperpolarized [formula: see text] c mri
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084843/
https://www.ncbi.nlm.nih.gov/pubmed/33740165
http://dx.doi.org/10.1007/s11060-021-03725-7
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