Cargando…
N-Acetyl-l-leucine improves functional recovery and attenuates cortical cell death and neuroinflammation after traumatic brain injury in mice
Traumatic brain injury (TBI) is a major cause of mortality and long-term disability around the world. Even mild to moderate TBI can lead to lifelong neurological impairment due to acute and progressive neurodegeneration and neuroinflammation induced by the injury. Thus, the discovery of novel treatm...
Autores principales: | Hegdekar, Nivedita, Lipinski, Marta M., Sarkar, Chinmoy |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8084982/ https://www.ncbi.nlm.nih.gov/pubmed/33927281 http://dx.doi.org/10.1038/s41598-021-88693-8 |
Ejemplares similares
-
N-acetyl-L-leucine: a promising treatment option for traumatic brain injury
por: Sarkar, Chinmoy, et al.
Publicado: (2022) -
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma
por: Sarkar, Chinmoy, et al.
Publicado: (2019) -
The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability
por: Thayer, Julia A., et al.
Publicado: (2019) -
Inhibition of autophagy in microglia and macrophages exacerbates innate immune responses and worsens brain injury outcomes
por: Hegdekar, Nivedita, et al.
Publicado: (2023) -
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury
por: Sarkar, Chinmoy, et al.
Publicado: (2015)