Dissociation of disease onset, progression and sex differences from androgen receptor levels in a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder caused by loss of motor neurons. ALS incidence is skewed towards males with typically earlier age of onset and limb site of onset. The androgen receptor (AR) is the major mediator of androgen effects in the body and is...

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Detalles Bibliográficos
Autores principales: Tomas, Doris, McLeod, Victoria M., Chiam, Mathew D. F., Wanniarachchillage, Nayomi, Boon, Wah C., Turner, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085012/
https://www.ncbi.nlm.nih.gov/pubmed/33927243
http://dx.doi.org/10.1038/s41598-021-88415-0

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