The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors

The maturation of coronavirus SARS-CoV-2, which is the etiological agent at the origin of the COVID-19 pandemic, requires a main protease M(pro) to cleave the virus-encoded polyproteins. Despite a wealth of experimental information already available, there is wide disagreement about the M(pro) monom...

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Detalles Bibliográficos
Autores principales: Silvestrini, Lucia, Belhaj, Norhan, Comez, Lucia, Gerelli, Yuri, Lauria, Antonino, Libera, Valeria, Mariani, Paolo, Marzullo, Paola, Ortore, Maria Grazia, Palumbo Piccionello, Antonio, Petrillo, Caterina, Savini, Lucrezia, Paciaroni, Alessandro, Spinozzi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085067/
https://www.ncbi.nlm.nih.gov/pubmed/33927258
http://dx.doi.org/10.1038/s41598-021-88630-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085067/
https://www.ncbi.nlm.nih.gov/pubmed/33927258
http://dx.doi.org/10.1038/s41598-021-88630-9

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