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D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast

BACKGROUND & OBJECTIVE: Breast cancer is the most common malignancy among Iranian women and worldwide. Lymphatic vessel invasion (LVI) was found to be an independent prognostic factor in many carcinomas, including invasive carcinoma of the breast. The aim of this study was to compare the hematox...

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Autores principales: Vosough, Zeinab, Golbini, Shima, Sharbatdaran, Majid, Hosseini, Akramossadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085290/
https://www.ncbi.nlm.nih.gov/pubmed/33936219
http://dx.doi.org/10.30699/IJP.2020.114511.2245
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author Vosough, Zeinab
Golbini, Shima
Sharbatdaran, Majid
Hosseini, Akramossadat
author_facet Vosough, Zeinab
Golbini, Shima
Sharbatdaran, Majid
Hosseini, Akramossadat
author_sort Vosough, Zeinab
collection PubMed
description BACKGROUND & OBJECTIVE: Breast cancer is the most common malignancy among Iranian women and worldwide. Lymphatic vessel invasion (LVI) was found to be an independent prognostic factor in many carcinomas, including invasive carcinoma of the breast. The aim of this study was to compare the hematoxylin and eosin (H&E) staining method and use of the immunohistochemical (IHC) marker ofD2-40, for evaluation of LVI in breast carcinoma specimens. METHODS: The study was conducted on 50 patients undergone surgery between the years 2010 and 2015 in Rohani Hospital, Babol, Iran with invasive carcinoma of the breast with Census sampling method. LVI was assessed by two surgical pathologists, using H&E- stained sections and two IHC markers, i.e., D2-40 and CD31. RESULTS: LVI was detected in 25 (50%) patients by H&E and in 14 (28%) patients by D2-40. Twelve out of 25 patients with positive LVI in H&E were confirmed by D2-40 and 2 out of 25 patients with negative lymphatic vessel in H&E. Only one case showed weak staining of CD31 proving LVI. These results showed a significant difference between the H&E staining and D2-40 IHC study for LVI detection (P=0.004). CONCLUSION: The D2-40 IHC marker is helpful in the diagnosis and confirmation of LVI in invasive carcinoma of the breast. CD31 is not suitable for the evaluation of lymphatic vessels.
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spelling pubmed-80852902021-04-30 D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast Vosough, Zeinab Golbini, Shima Sharbatdaran, Majid Hosseini, Akramossadat Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Breast cancer is the most common malignancy among Iranian women and worldwide. Lymphatic vessel invasion (LVI) was found to be an independent prognostic factor in many carcinomas, including invasive carcinoma of the breast. The aim of this study was to compare the hematoxylin and eosin (H&E) staining method and use of the immunohistochemical (IHC) marker ofD2-40, for evaluation of LVI in breast carcinoma specimens. METHODS: The study was conducted on 50 patients undergone surgery between the years 2010 and 2015 in Rohani Hospital, Babol, Iran with invasive carcinoma of the breast with Census sampling method. LVI was assessed by two surgical pathologists, using H&E- stained sections and two IHC markers, i.e., D2-40 and CD31. RESULTS: LVI was detected in 25 (50%) patients by H&E and in 14 (28%) patients by D2-40. Twelve out of 25 patients with positive LVI in H&E were confirmed by D2-40 and 2 out of 25 patients with negative lymphatic vessel in H&E. Only one case showed weak staining of CD31 proving LVI. These results showed a significant difference between the H&E staining and D2-40 IHC study for LVI detection (P=0.004). CONCLUSION: The D2-40 IHC marker is helpful in the diagnosis and confirmation of LVI in invasive carcinoma of the breast. CD31 is not suitable for the evaluation of lymphatic vessels. Iranian Society of Pathology 2021 2020-12-20 /pmc/articles/PMC8085290/ /pubmed/33936219 http://dx.doi.org/10.30699/IJP.2020.114511.2245 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution- 4.0 International License, (https://creativecommons.org/licenses/by/4.0/) which permits Share, copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, even commercially
spellingShingle Original Article
Vosough, Zeinab
Golbini, Shima
Sharbatdaran, Majid
Hosseini, Akramossadat
D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast
title D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast
title_full D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast
title_fullStr D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast
title_full_unstemmed D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast
title_short D2-40 A Helpful Marker in Assessment of Lymphatic Vessel Invasion in Carcinoma of Breast
title_sort d2-40 a helpful marker in assessment of lymphatic vessel invasion in carcinoma of breast
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085290/
https://www.ncbi.nlm.nih.gov/pubmed/33936219
http://dx.doi.org/10.30699/IJP.2020.114511.2245
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