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Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission

BACKGROUND & OBJECTIVE: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a gr...

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Autores principales: Mirsadraee, Saeed, Pourabrollah Toutkaboni, Mihan, Bakhshayeshkaram, Mehrdad, Rezaei, Mitrasadat, Askari, Elham, Haseli, Sara, Sadraee, Nazanin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society of Pathology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085293/
https://www.ncbi.nlm.nih.gov/pubmed/33936224
http://dx.doi.org/10.30699/IJP.2020.128909.2415
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author Mirsadraee, Saeed
Pourabrollah Toutkaboni, Mihan
Bakhshayeshkaram, Mehrdad
Rezaei, Mitrasadat
Askari, Elham
Haseli, Sara
Sadraee, Nazanin
author_facet Mirsadraee, Saeed
Pourabrollah Toutkaboni, Mihan
Bakhshayeshkaram, Mehrdad
Rezaei, Mitrasadat
Askari, Elham
Haseli, Sara
Sadraee, Nazanin
author_sort Mirsadraee, Saeed
collection PubMed
description BACKGROUND & OBJECTIVE: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a group of patients with a multidisciplinary diagnosis of COVID-19 pneumonia. METHODS: A total of 163 patients with a clinical diagnosis of COVID-19 pneumonia admitted to a specialised respiratory centre in Tehran, Iran were enrolled in this study. The distribution and characteristics of presenting radiological and laboratory findings were evaluated and the relationship to the outcome was investigated. RESULTS: RT­PCR was positive in 92 patients. The diagnosis of COVID-19 in RT-PCR negative patients was made on clinical and radiological features (n=71) and 24 (14.7%) patients died of disease. The common computed tomography (CT) scan findings included ground-glass (94%) and consolidating opacification (12%), mainly in the lower lobes (90%). Peripheral and central lung changes were observed in 90% and 52% of patients, respectively. Lymphopenia, positive CRP, and raised LDH were present in 32%, 65%, and 96% of cases, respectively. A raised LDH of >500U/L was the best predictor of death in these patients (R(2)=0.6623; OR=24.4). Other markers of outcome included male gender, age (>50 years), lymphopenia, and severe CXR changes. CONCLUSION: Diagnosis of COVID-19 can be challenging, and a multidisciplinary approach is often needed. Whilst RT-PCR is still the standard diagnostic test, a negative test should be interpreted with caution. Blood tests and imaging can be useful in the diagnosis, monitoring, and risk assessment in patients with COVID-19.
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spelling pubmed-80852932021-04-30 Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission Mirsadraee, Saeed Pourabrollah Toutkaboni, Mihan Bakhshayeshkaram, Mehrdad Rezaei, Mitrasadat Askari, Elham Haseli, Sara Sadraee, Nazanin Iran J Pathol Original Article BACKGROUND & OBJECTIVE: Diagnosis of coronavirus disease 2019 (COVID-19) can be challenging, especially when the real-time quantitative reverse transcription polymerase chain reaction (RT-PCR) is not available or it is negative. In this study, we evaluated imaging and laboratory findings in a group of patients with a multidisciplinary diagnosis of COVID-19 pneumonia. METHODS: A total of 163 patients with a clinical diagnosis of COVID-19 pneumonia admitted to a specialised respiratory centre in Tehran, Iran were enrolled in this study. The distribution and characteristics of presenting radiological and laboratory findings were evaluated and the relationship to the outcome was investigated. RESULTS: RT­PCR was positive in 92 patients. The diagnosis of COVID-19 in RT-PCR negative patients was made on clinical and radiological features (n=71) and 24 (14.7%) patients died of disease. The common computed tomography (CT) scan findings included ground-glass (94%) and consolidating opacification (12%), mainly in the lower lobes (90%). Peripheral and central lung changes were observed in 90% and 52% of patients, respectively. Lymphopenia, positive CRP, and raised LDH were present in 32%, 65%, and 96% of cases, respectively. A raised LDH of >500U/L was the best predictor of death in these patients (R(2)=0.6623; OR=24.4). Other markers of outcome included male gender, age (>50 years), lymphopenia, and severe CXR changes. CONCLUSION: Diagnosis of COVID-19 can be challenging, and a multidisciplinary approach is often needed. Whilst RT-PCR is still the standard diagnostic test, a negative test should be interpreted with caution. Blood tests and imaging can be useful in the diagnosis, monitoring, and risk assessment in patients with COVID-19. Iranian Society of Pathology 2021 2020-10-21 /pmc/articles/PMC8085293/ /pubmed/33936224 http://dx.doi.org/10.30699/IJP.2020.128909.2415 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution- 4.0 International License, (https://creativecommons.org/licenses/by/4.0/) which permits Share, copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, even commercially
spellingShingle Original Article
Mirsadraee, Saeed
Pourabrollah Toutkaboni, Mihan
Bakhshayeshkaram, Mehrdad
Rezaei, Mitrasadat
Askari, Elham
Haseli, Sara
Sadraee, Nazanin
Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission
title Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission
title_full Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission
title_fullStr Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission
title_full_unstemmed Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission
title_short Radiological and Laboratory Findings of Patients with COVID-19 Infection at the Time of Admission
title_sort radiological and laboratory findings of patients with covid-19 infection at the time of admission
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085293/
https://www.ncbi.nlm.nih.gov/pubmed/33936224
http://dx.doi.org/10.30699/IJP.2020.128909.2415
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