Cargando…

Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster

When organisms’ environmental conditions vary unpredictably in time, it can be advantageous for individuals to hedge their phenotypic bets. It has been shown that a bet-hedging strategy possibly underlies the high inter-individual diversity of phototactic choice in Drosophila melanogaster. This stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Krams, Indrikis A., Krama, Tatjana, Krams, Ronalds, Trakimas, Giedrius, Popovs, Sergejs, Jõers, Priit, Munkevics, Maris, Elferts, Didzis, Rantala, Markus J., Makņa, Jānis, de Bivort, Benjamin L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085305/
https://www.ncbi.nlm.nih.gov/pubmed/33935664
http://dx.doi.org/10.3389/fnbeh.2021.659331
_version_ 1783686309055823872
author Krams, Indrikis A.
Krama, Tatjana
Krams, Ronalds
Trakimas, Giedrius
Popovs, Sergejs
Jõers, Priit
Munkevics, Maris
Elferts, Didzis
Rantala, Markus J.
Makņa, Jānis
de Bivort, Benjamin L.
author_facet Krams, Indrikis A.
Krama, Tatjana
Krams, Ronalds
Trakimas, Giedrius
Popovs, Sergejs
Jõers, Priit
Munkevics, Maris
Elferts, Didzis
Rantala, Markus J.
Makņa, Jānis
de Bivort, Benjamin L.
author_sort Krams, Indrikis A.
collection PubMed
description When organisms’ environmental conditions vary unpredictably in time, it can be advantageous for individuals to hedge their phenotypic bets. It has been shown that a bet-hedging strategy possibly underlies the high inter-individual diversity of phototactic choice in Drosophila melanogaster. This study shows that fruit flies from a population living in a boreal and relatively unpredictable climate have more variable variable phototactic biases than fruit flies from a more stable tropical climate, consistent with bet-hedging theory. We experimentally show that phototactic variability of D. melanogaster is regulated by the neurotransmitter serotonin (5-HT), which acts as a suppressor of the variability of phototactic choices. When fed 5-HT precursor, boreal flies exhibited lower variability, and they were insensitive to 5-HT inhibitor. The opposite pattern was seen in the tropical flies. Thus, the reduction of 5-HT in fruit flies’ brains may be the mechanistic basis of an adaptive bet-hedging strategy in a less predictable boreal climate.
format Online
Article
Text
id pubmed-8085305
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80853052021-05-01 Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster Krams, Indrikis A. Krama, Tatjana Krams, Ronalds Trakimas, Giedrius Popovs, Sergejs Jõers, Priit Munkevics, Maris Elferts, Didzis Rantala, Markus J. Makņa, Jānis de Bivort, Benjamin L. Front Behav Neurosci Behavioral Neuroscience When organisms’ environmental conditions vary unpredictably in time, it can be advantageous for individuals to hedge their phenotypic bets. It has been shown that a bet-hedging strategy possibly underlies the high inter-individual diversity of phototactic choice in Drosophila melanogaster. This study shows that fruit flies from a population living in a boreal and relatively unpredictable climate have more variable variable phototactic biases than fruit flies from a more stable tropical climate, consistent with bet-hedging theory. We experimentally show that phototactic variability of D. melanogaster is regulated by the neurotransmitter serotonin (5-HT), which acts as a suppressor of the variability of phototactic choices. When fed 5-HT precursor, boreal flies exhibited lower variability, and they were insensitive to 5-HT inhibitor. The opposite pattern was seen in the tropical flies. Thus, the reduction of 5-HT in fruit flies’ brains may be the mechanistic basis of an adaptive bet-hedging strategy in a less predictable boreal climate. Frontiers Media S.A. 2021-04-16 /pmc/articles/PMC8085305/ /pubmed/33935664 http://dx.doi.org/10.3389/fnbeh.2021.659331 Text en Copyright © 2021 Krams, Krama, Krams, Trakimas, Popovs, Jõers, Munkevics, Elferts, Rantala, Makņa and de Bivort. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Krams, Indrikis A.
Krama, Tatjana
Krams, Ronalds
Trakimas, Giedrius
Popovs, Sergejs
Jõers, Priit
Munkevics, Maris
Elferts, Didzis
Rantala, Markus J.
Makņa, Jānis
de Bivort, Benjamin L.
Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
title Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
title_full Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
title_fullStr Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
title_full_unstemmed Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
title_short Serotoninergic Modulation of Phototactic Variability Underpins a Bet-Hedging Strategy in Drosophila melanogaster
title_sort serotoninergic modulation of phototactic variability underpins a bet-hedging strategy in drosophila melanogaster
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085305/
https://www.ncbi.nlm.nih.gov/pubmed/33935664
http://dx.doi.org/10.3389/fnbeh.2021.659331
work_keys_str_mv AT kramsindrikisa serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT kramatatjana serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT kramsronalds serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT trakimasgiedrius serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT popovssergejs serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT joerspriit serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT munkevicsmaris serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT elfertsdidzis serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT rantalamarkusj serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT maknajanis serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster
AT debivortbenjaminl serotoninergicmodulationofphototacticvariabilityunderpinsabethedgingstrategyindrosophilamelanogaster