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3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone

The Vagal Trigone, often referred to as Ala Cinerea, is a triangular-shaped area of the floor of the fourth ventricle that is strictly involved in the network of chardiochronotropic, baroceptive, respiratory, and gastrointestinal control systems of the medulla oblongata. While it is frequently ident...

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Autores principales: Emmi, Aron, Porzionato, Andrea, Contran, Martina, De Rose, Enrico, Macchi, Veronica, De Caro, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085322/
https://www.ncbi.nlm.nih.gov/pubmed/33935659
http://dx.doi.org/10.3389/fnana.2021.663399
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author Emmi, Aron
Porzionato, Andrea
Contran, Martina
De Rose, Enrico
Macchi, Veronica
De Caro, Raffaele
author_facet Emmi, Aron
Porzionato, Andrea
Contran, Martina
De Rose, Enrico
Macchi, Veronica
De Caro, Raffaele
author_sort Emmi, Aron
collection PubMed
description The Vagal Trigone, often referred to as Ala Cinerea, is a triangular-shaped area of the floor of the fourth ventricle that is strictly involved in the network of chardiochronotropic, baroceptive, respiratory, and gastrointestinal control systems of the medulla oblongata. While it is frequently identified as the superficial landmark for the underlying Dorsal Motor Nucleus of the Vagus, this correspondence is not univocal in anatomical literature and is often oversimplified in neuroanatomy textbooks and neurosurgical atlases. As the structure represents an important landmark for neurosurgical procedures involving the floor of the fourth ventricle, accurate morphological characterization is required to avoid unwanted side effects (e.g., bradychardia, hypertension) during neuorphysiological monitoring and cranial nerve nuclei stimulation in intraoperative settings. The aim of this study was to address the anatomo-topographical relationships of the Vagal Trigone with the underlying nuclei. For this purpose, we have conducted an anatomo-microscopical examination of serial sections deriving from 54 Human Brainstems followed by 3D reconstruction and rendering of the specimens. Our findings indicate that the Vagal Trigone corresponds only partially with the Dorsal Motor Nucleus of the Vagus, while most of its axial profile is occupied by the dorsal regions of the Solitary Tract Nucleus. Furthermore, basing on literature and our findings we speculate that the neuroblasts of the Dorsal Motor Nucleus of the Vagus undergo neurobiotaxic migration induced by the neuroblasts of the dorsolaterally located solitary tract nucleus, giving rise to the Ala Cinerea, a topographically defined area for parasympathetic visceral control.
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spelling pubmed-80853222021-05-01 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone Emmi, Aron Porzionato, Andrea Contran, Martina De Rose, Enrico Macchi, Veronica De Caro, Raffaele Front Neuroanat Neuroscience The Vagal Trigone, often referred to as Ala Cinerea, is a triangular-shaped area of the floor of the fourth ventricle that is strictly involved in the network of chardiochronotropic, baroceptive, respiratory, and gastrointestinal control systems of the medulla oblongata. While it is frequently identified as the superficial landmark for the underlying Dorsal Motor Nucleus of the Vagus, this correspondence is not univocal in anatomical literature and is often oversimplified in neuroanatomy textbooks and neurosurgical atlases. As the structure represents an important landmark for neurosurgical procedures involving the floor of the fourth ventricle, accurate morphological characterization is required to avoid unwanted side effects (e.g., bradychardia, hypertension) during neuorphysiological monitoring and cranial nerve nuclei stimulation in intraoperative settings. The aim of this study was to address the anatomo-topographical relationships of the Vagal Trigone with the underlying nuclei. For this purpose, we have conducted an anatomo-microscopical examination of serial sections deriving from 54 Human Brainstems followed by 3D reconstruction and rendering of the specimens. Our findings indicate that the Vagal Trigone corresponds only partially with the Dorsal Motor Nucleus of the Vagus, while most of its axial profile is occupied by the dorsal regions of the Solitary Tract Nucleus. Furthermore, basing on literature and our findings we speculate that the neuroblasts of the Dorsal Motor Nucleus of the Vagus undergo neurobiotaxic migration induced by the neuroblasts of the dorsolaterally located solitary tract nucleus, giving rise to the Ala Cinerea, a topographically defined area for parasympathetic visceral control. Frontiers Media S.A. 2021-04-16 /pmc/articles/PMC8085322/ /pubmed/33935659 http://dx.doi.org/10.3389/fnana.2021.663399 Text en Copyright © 2021 Emmi, Porzionato, Contran, De Rose, Macchi and De Caro. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Emmi, Aron
Porzionato, Andrea
Contran, Martina
De Rose, Enrico
Macchi, Veronica
De Caro, Raffaele
3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone
title 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone
title_full 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone
title_fullStr 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone
title_full_unstemmed 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone
title_short 3D Reconstruction of the Morpho-Functional Topography of the Human Vagal Trigone
title_sort 3d reconstruction of the morpho-functional topography of the human vagal trigone
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085322/
https://www.ncbi.nlm.nih.gov/pubmed/33935659
http://dx.doi.org/10.3389/fnana.2021.663399
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