Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates

The Comprehensive, Computable NanoString Diagnostic gene panel (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Sm...

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Detalles Bibliográficos
Autores principales: Su, Jing, Huang, Lynn S., Barnard, Ryan, Parks, Graham, Cappellari, James, Bellinger, Christina, Dotson, Travis, Craddock, Lou, Prakash, Bharat, Hovda, Jonathan, Clark, Hollins, Petty, William Jeffrey, Pasche, Boris, Chan, Michael D., Miller, Lance D., Ruiz, Jimmy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085404/
https://www.ncbi.nlm.nih.gov/pubmed/33937015
http://dx.doi.org/10.3389/fonc.2021.584896
Descripción
Sumario:The Comprehensive, Computable NanoString Diagnostic gene panel (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Small Cell Lung Cancer (NSCLC) derived from public transcriptomic data which establish a highly robust and accurate subtyping system. The C2Dx demonstrates supreme performance on the NanoString platform using microgram-level FNA samples and has excellent portability to frozen tissues and RNA-Seq transcriptomic data. This workflow shows great potential for research and the clinical practice of cancer molecular diagnosis.

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