Cargando…

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

Epithelial-to-mesenchymal transition (EMT), a complicated program through which polarized epithelial cells acquire motile mesothelial traits, is regulated by tumor microenvironment. EMT is involved in tumor progression, invasion and metastasis via reconstructing the cytoskeleton and degrading the tu...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Kaibo, Feng, Yuqian, Zheng, Xueer, Sun, Leitao, Wasan, Harpreet S., Ruan, Shanming, Shen, Minhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085503/
https://www.ncbi.nlm.nih.gov/pubmed/33937049
http://dx.doi.org/10.3389/fonc.2021.644134
_version_ 1783686354516836352
author Guo, Kaibo
Feng, Yuqian
Zheng, Xueer
Sun, Leitao
Wasan, Harpreet S.
Ruan, Shanming
Shen, Minhe
author_facet Guo, Kaibo
Feng, Yuqian
Zheng, Xueer
Sun, Leitao
Wasan, Harpreet S.
Ruan, Shanming
Shen, Minhe
author_sort Guo, Kaibo
collection PubMed
description Epithelial-to-mesenchymal transition (EMT), a complicated program through which polarized epithelial cells acquire motile mesothelial traits, is regulated by tumor microenvironment. EMT is involved in tumor progression, invasion and metastasis via reconstructing the cytoskeleton and degrading the tumor basement membrane. Accumulating evidence shows that resveratrol, as a non-flavonoid polyphenol, can reverse EMT and inhibit invasion and migration of human tumors via diverse mechanisms and signaling pathways. In the present review, we will summarize the detailed mechanisms and pathways by which resveratrol and its analogs (e.g. Triacetyl resveratrol, 3,5,4’-Trimethoxystilbene) might regulate the EMT process in cancer cells to better understand their potential as novel anti-tumor agents. Resveratrol can also reverse chemoresistance via EMT inhibition and improvement of the antiproliferative effects of conventional treatments. Therefore, resveratrol and its analogs have the potential to become novel adjunctive agents to inhibit cancer metastasis, which might be partly related to their blocking of the EMT process.
format Online
Article
Text
id pubmed-8085503
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-80855032021-05-01 Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors Guo, Kaibo Feng, Yuqian Zheng, Xueer Sun, Leitao Wasan, Harpreet S. Ruan, Shanming Shen, Minhe Front Oncol Oncology Epithelial-to-mesenchymal transition (EMT), a complicated program through which polarized epithelial cells acquire motile mesothelial traits, is regulated by tumor microenvironment. EMT is involved in tumor progression, invasion and metastasis via reconstructing the cytoskeleton and degrading the tumor basement membrane. Accumulating evidence shows that resveratrol, as a non-flavonoid polyphenol, can reverse EMT and inhibit invasion and migration of human tumors via diverse mechanisms and signaling pathways. In the present review, we will summarize the detailed mechanisms and pathways by which resveratrol and its analogs (e.g. Triacetyl resveratrol, 3,5,4’-Trimethoxystilbene) might regulate the EMT process in cancer cells to better understand their potential as novel anti-tumor agents. Resveratrol can also reverse chemoresistance via EMT inhibition and improvement of the antiproliferative effects of conventional treatments. Therefore, resveratrol and its analogs have the potential to become novel adjunctive agents to inhibit cancer metastasis, which might be partly related to their blocking of the EMT process. Frontiers Media S.A. 2021-04-16 /pmc/articles/PMC8085503/ /pubmed/33937049 http://dx.doi.org/10.3389/fonc.2021.644134 Text en Copyright © 2021 Guo, Feng, Zheng, Sun, Wasan, Ruan and Shen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Guo, Kaibo
Feng, Yuqian
Zheng, Xueer
Sun, Leitao
Wasan, Harpreet S.
Ruan, Shanming
Shen, Minhe
Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
title Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
title_full Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
title_fullStr Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
title_full_unstemmed Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
title_short Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors
title_sort resveratrol and its analogs: potent agents to reverse epithelial-to-mesenchymal transition in tumors
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085503/
https://www.ncbi.nlm.nih.gov/pubmed/33937049
http://dx.doi.org/10.3389/fonc.2021.644134
work_keys_str_mv AT guokaibo resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors
AT fengyuqian resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors
AT zhengxueer resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors
AT sunleitao resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors
AT wasanharpreets resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors
AT ruanshanming resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors
AT shenminhe resveratrolanditsanalogspotentagentstoreverseepithelialtomesenchymaltransitionintumors