Cargando…

Transcriptional profiling of the stringent response mutant strain E. coli SR reveals enhanced robustness to large‐scale conditions

In large‐scale fed‐batch production processes, microbes are exposed to heterogeneous substrate availability caused by long mixing times. Escherichia coli, the most common industrial host for recombinant protein production, reacts by recurring accumulation of the alarmone ppGpp and energetically wast...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ziegler, Martin, Zieringer, Julia, Takors, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085953/ https://www.ncbi.nlm.nih.gov/pubmed/33369128 http://dx.doi.org/10.1111/1751-7915.13738

Ejemplares similares

In Silico Prediction of Large-Scale Microbial Production Performance: Constraints for Getting Proper Data-Driven Models
por: Zieringer, Julia, et al.
Publicado: (2018)

Methylthioadenosine (MTA) boosts cell‐specific productivities of Chinese hamster ovary cultures: dosage effects on proliferation, cell cycle and gene expression
por: Verhagen, Natascha, et al.
Publicado: (2020)

Physiological Response of Corynebacterium glutamicum to Increasingly Nutrient-Rich Growth Conditions
por: Graf, Michaela, et al.
Publicado: (2018)

Synthetic mutualism in engineered E. coli mutant strains as functional basis for microbial production consortia
por: Müller, Tobias, et al.
Publicado: (2022)

The Stringent Response and Cell Cycle Arrest in Escherichia coli
por: Ferullo, Daniel J., et al.
Publicado: (2008)

Stringent Response and AggR-Dependent Virulence Regulation in the Enteroaggregative Escherichia coli Strain 042
por: Hüttener, Mário, et al.
Publicado: (2018)

CRISPRi enables fast growth followed by stable aerobic pyruvate formation in Escherichia coli without auxotrophy
por: Ziegler, Martin, et al.
Publicado: (2021)

Lagrangian Trajectories to Predict the Formation of Population Heterogeneity in Large-Scale Bioreactors
por: Kuschel, Maike, et al.
Publicado: (2017)

Nitrogen stress response and stringent response are coupled in Escherichia coli
por: Brown, Daniel R., et al.
Publicado: (2014)

Repetitive Short-Term Stimuli Imposed in Poor Mixing Zones Induce Long-Term Adaptation of E. coli Cultures in Large-Scale Bioreactors: Experimental Evidence and Mathematical Model
por: Nieß, Alexander, et al.
Publicado: (2017)

Stringent response of Escherichia coli: revisiting the bibliome using literature mining
por: Carneiro, Sónia, et al.
Publicado: (2011)

Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA
por: Turnbull, Kathryn Jane, et al.
Publicado: (2019)

Robust mutant strain design by pessimistic optimization
por: Apaydin, Meltem, et al.
Publicado: (2017)

Data on the transcriptional response to MESH1 knockdown and mammalian stringent response
por: Sun, Tianai, et al.
Publicado: (2023)

Comprehensive Analysis of C. glutamicum Anaplerotic Deletion Mutants Under Defined d-Glucose Conditions
por: Kappelmann, Jannick, et al.
Publicado: (2021)

YtfK activates the stringent response by triggering the alarmone synthetase SpoT in Escherichia coli
por: Germain, Elsa, et al.
Publicado: (2019)

NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli
por: Léger, Loïc, et al.
Publicado: (2021)

The Crohn’s disease-associated Escherichia coli strain LF82 relies on SOS and stringent responses to survive, multiply and tolerate antibiotics within macrophages
por: Demarre, Gaëlle, et al.
Publicado: (2019)

Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response
por: Islam, Sabina, et al.
Publicado: (2015)

The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC
por: Kraemer, James A., et al.
Publicado: (2019)

Containing COVID-19: Implementation of Early and Moderately Stringent Social Distancing Measures Can Prevent The Need for Large-Scale Lockdowns
por: Koh, Wee Chian, et al.
Publicado: (2020)

Large-scale genomic sequencing of extraintestinal pathogenic Escherichia coli strains
por: Salipante, Stephen J., et al.
Publicado: (2015)

Phenotypic heterogeneity in mycobacterial stringent response
por: Ghosh, Sayantari, et al.
Publicado: (2011)

Ribosome-dependent activation of stringent control
por: Brown, Alan, et al.
Publicado: (2016)

Performing in spite of starvation: How Saccharomyces cerevisiae maintains robust growth when facing famine zones in industrial bioreactors
por: Minden, Steven, et al.
Publicado: (2022)

ATP-Induced IL-1β Specific Secretion: True Under Stringent Conditions
por: Stoffels, Monique, et al.
Publicado: (2015)

Pseudomonas putida KT2440 is naturally endowed to withstand industrial‐scale stress conditions
por: Ankenbauer, Andreas, et al.
Publicado: (2020)

Protein production in Escherichia coli is guided by the trade-off between intracellular substrate availability and energy cost
por: Nieß, Alexander, et al.
Publicado: (2019)

Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli
por: Varik, Vallo, et al.
Publicado: (2016)

Transcriptional response of Escherichia coli to ammonia and glucose fluctuations
por: Simen, Joana Danica, et al.
Publicado: (2017)

Genetic components of stringent response in Vibrio cholerae
por: Pal, Ritesh Ranjan, et al.
Publicado: (2011)

Although it's painful: The importance of stringent antibody validation
por: Meliopoulos, Victoria A., et al.
Publicado: (2018)

Understanding the Stringent Response: Experimental Context Matters
por: Dworkin, Jonathan
Publicado: (2023)

Deterministic evolution and stringent selection during preneoplasia
por: Karlsson, Kasper, et al.
Publicado: (2023)

Stringent test of QED with hydrogen-like tin
por: Morgner, J., et al.
Publicado: (2023)

Synergistically applying 1‐D modeling and CFD for designing industrial scale bubble column syngas bioreactors
por: Siebler, Flora, et al.
Publicado: (2020)

Robust linear DNA degradation supports replication–initiation-defective mutants in Escherichia coli
por: Rao, T V Pritha, et al.
Publicado: (2022)

Robust large-scale clustering based on correntropy
por: Jin, Guodong, et al.
Publicado: (2022)

The Stringent Stress Response Controls Proteases and Global Regulators under Optimal Growth Conditions in Pseudomonas aeruginosa
por: Pletzer, Daniel, et al.
Publicado: (2020)

Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light
por: Chen, Xianjun, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_gctvvstolidd6t9sh753ib05vh