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Rapid response to emerging biomedical challenges and threats

As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural dat...

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Detalles Bibliográficos
Autores principales: Grabowski, Marek, Macnar, Joanna M., Cymborowski, Marcin, Cooper, David R., Shabalin, Ivan G., Gilski, Miroslaw, Brzezinski, Dariusz, Kowiel, Marcin, Dauter, Zbigniew, Rupp, Bernhard, Wlodawer, Alexander, Jaskolski, Mariusz, Minor, Wladek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086160/
https://www.ncbi.nlm.nih.gov/pubmed/33953926
http://dx.doi.org/10.1107/S2052252521003018
Descripción
Sumario:As part of the global mobilization to combat the present pandemic, almost 100 000 COVID-19-related papers have been published and nearly a thousand models of macromolecules encoded by SARS-CoV-2 have been deposited in the Protein Data Bank within less than a year. The avalanche of new structural data has given rise to multiple resources dedicated to assessing the correctness and quality of structural data and models. Here, an approach to evaluate the massive amounts of such data using the resource https://covid19.bioreproducibility.org is described, which offers a template that could be used in large-scale initiatives undertaken in response to future biomedical crises. Broader use of the described methodology could considerably curtail information noise and significantly improve the reproducibility of biomedical research.