Adhesion G protein-coupled receptors in glioblastoma

BACKGROUND: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. METHODS: Here, we discuss t...

Descripción completa

Detalles Bibliográficos
Autores principales: Stephan, Gabriele, Ravn-Boess, Niklas, Placantonakis, Dimitris G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086243/
https://www.ncbi.nlm.nih.gov/pubmed/33959717
http://dx.doi.org/10.1093/noajnl/vdab046
Descripción
Sumario:BACKGROUND: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. METHODS: Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology.

Ejemplares similares