Adhesion G protein-coupled receptors in glioblastoma

BACKGROUND: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. METHODS: Here, we discuss t...

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Detalles Bibliográficos
Autores principales: Stephan, Gabriele, Ravn-Boess, Niklas, Placantonakis, Dimitris G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086243/
https://www.ncbi.nlm.nih.gov/pubmed/33959717
http://dx.doi.org/10.1093/noajnl/vdab046
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author Stephan, Gabriele
Ravn-Boess, Niklas
Placantonakis, Dimitris G
author_facet Stephan, Gabriele
Ravn-Boess, Niklas
Placantonakis, Dimitris G
author_sort Stephan, Gabriele
collection PubMed
description BACKGROUND: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. METHODS: Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology.
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spelling pubmed-80862432021-05-05 Adhesion G protein-coupled receptors in glioblastoma Stephan, Gabriele Ravn-Boess, Niklas Placantonakis, Dimitris G Neurooncol Adv Reviews BACKGROUND: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma. METHODS: Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Finally, we discuss the potential use of adhesion GPCRs as novel treatment targets in neuro-oncology. Oxford University Press 2021-03-23 /pmc/articles/PMC8086243/ /pubmed/33959717 http://dx.doi.org/10.1093/noajnl/vdab046 Text en © The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Stephan, Gabriele
Ravn-Boess, Niklas
Placantonakis, Dimitris G
Adhesion G protein-coupled receptors in glioblastoma
title Adhesion G protein-coupled receptors in glioblastoma
title_full Adhesion G protein-coupled receptors in glioblastoma
title_fullStr Adhesion G protein-coupled receptors in glioblastoma
title_full_unstemmed Adhesion G protein-coupled receptors in glioblastoma
title_short Adhesion G protein-coupled receptors in glioblastoma
title_sort adhesion g protein-coupled receptors in glioblastoma
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086243/
https://www.ncbi.nlm.nih.gov/pubmed/33959717
http://dx.doi.org/10.1093/noajnl/vdab046
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