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Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019
BACKGROUND: Healthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals. AIM: We investigated whether Danish paediatric HCW were protected against selected serious VPD. METHODS: We included 90% of staff members from two paediat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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European Centre for Disease Prevention and Control (ECDC)
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086246/ https://www.ncbi.nlm.nih.gov/pubmed/33928900 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.17.2001167 |
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author | von Linstow, Marie-Louise Yde Nielsen, Alex Kirkby, Nikolai Eltvedt, Anna Nordmann Winther, Thilde Bybeck Nielsen, Allan Bang, Didi Poulsen, Anja |
author_facet | von Linstow, Marie-Louise Yde Nielsen, Alex Kirkby, Nikolai Eltvedt, Anna Nordmann Winther, Thilde Bybeck Nielsen, Allan Bang, Didi Poulsen, Anja |
author_sort | von Linstow, Marie-Louise |
collection | PubMed |
description | BACKGROUND: Healthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals. AIM: We investigated whether Danish paediatric HCW were protected against selected serious VPD. METHODS: We included 90% of staff members from two paediatric departments. All 555 HCW (496 women) supplied a blood sample for serology and filled in a questionnaire. Antibodies were measured with enzyme immunoassay against measles, mumps, rubella (MMR), varicella zoster, pertussis toxin and diphtheria toxin. RESULTS: Protective levels of IgG were found for measles (90.3%), mumps (86.5%), rubella (92.3%), varicella (98.6%) and diphtheria (80.5%). We found seropositivity for all three MMR components in 421 (75.9%) HCW, lowest in those younger than 36 years (63.3%). Only 28 (5%) HCW had measurable IgG to pertussis. HCW with self-reported immunity defined as previous infection or vaccination, had protective levels of IgG against measles, mumps, rubella and varicella in 87.4–98.8% of cases, not significantly higher than in those not reporting immunity. Previous history of disease had a high positive predictive value (PPV) of 96.8–98.8%. The PPV for previous vaccination ranged from 82.5% to 90.3%. In contrast, negative predictive values of self-reported history of disease and vaccination were remarkably low for all diseases. CONCLUSION: The immunity gaps found primarily in young HCW indicate a need for a screening and vaccination strategy for this group. Considering the poor correlation between self-reported immunity and seropositivity, efforts should be made to check HCW’s immune status in order to identify those who would benefit from vaccination. |
format | Online Article Text |
id | pubmed-8086246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-80862462021-05-06 Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 von Linstow, Marie-Louise Yde Nielsen, Alex Kirkby, Nikolai Eltvedt, Anna Nordmann Winther, Thilde Bybeck Nielsen, Allan Bang, Didi Poulsen, Anja Euro Surveill Research BACKGROUND: Healthcare workers (HCW) have been identified as index cases in disease outbreaks of vaccine-preventable diseases (VPD) in hospitals. AIM: We investigated whether Danish paediatric HCW were protected against selected serious VPD. METHODS: We included 90% of staff members from two paediatric departments. All 555 HCW (496 women) supplied a blood sample for serology and filled in a questionnaire. Antibodies were measured with enzyme immunoassay against measles, mumps, rubella (MMR), varicella zoster, pertussis toxin and diphtheria toxin. RESULTS: Protective levels of IgG were found for measles (90.3%), mumps (86.5%), rubella (92.3%), varicella (98.6%) and diphtheria (80.5%). We found seropositivity for all three MMR components in 421 (75.9%) HCW, lowest in those younger than 36 years (63.3%). Only 28 (5%) HCW had measurable IgG to pertussis. HCW with self-reported immunity defined as previous infection or vaccination, had protective levels of IgG against measles, mumps, rubella and varicella in 87.4–98.8% of cases, not significantly higher than in those not reporting immunity. Previous history of disease had a high positive predictive value (PPV) of 96.8–98.8%. The PPV for previous vaccination ranged from 82.5% to 90.3%. In contrast, negative predictive values of self-reported history of disease and vaccination were remarkably low for all diseases. CONCLUSION: The immunity gaps found primarily in young HCW indicate a need for a screening and vaccination strategy for this group. Considering the poor correlation between self-reported immunity and seropositivity, efforts should be made to check HCW’s immune status in order to identify those who would benefit from vaccination. European Centre for Disease Prevention and Control (ECDC) 2021-04-29 /pmc/articles/PMC8086246/ /pubmed/33928900 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.17.2001167 Text en This article is copyright of the authors or their affiliated institutions, 2021. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Research von Linstow, Marie-Louise Yde Nielsen, Alex Kirkby, Nikolai Eltvedt, Anna Nordmann Winther, Thilde Bybeck Nielsen, Allan Bang, Didi Poulsen, Anja Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 |
title | Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 |
title_full | Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 |
title_fullStr | Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 |
title_full_unstemmed | Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 |
title_short | Immunity to vaccine-preventable diseases among paediatric healthcare workers in Denmark, 2019 |
title_sort | immunity to vaccine-preventable diseases among paediatric healthcare workers in denmark, 2019 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086246/ https://www.ncbi.nlm.nih.gov/pubmed/33928900 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.17.2001167 |
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