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A systematic review of case reports of hepatic actinomycosis

BACKGROUND: Hepatic Actinomycosis (HA) is one of the infections that causes disorders in patients when diagnosed untimely and inappropriately. METHODS: Case reports on HA in patients published between 2000 and April 2020 were gathered by carrying out a structured search through PubMed/Medline. RESUL...

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Autores principales: Chegini, Zahra, Didehdar, Mojtaba, Tabaeian, Seidamir Pasha, Khoshbayan, Amin, Shariati, Aref
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086304/
https://www.ncbi.nlm.nih.gov/pubmed/33931097
http://dx.doi.org/10.1186/s13023-021-01821-5
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author Chegini, Zahra
Didehdar, Mojtaba
Tabaeian, Seidamir Pasha
Khoshbayan, Amin
Shariati, Aref
author_facet Chegini, Zahra
Didehdar, Mojtaba
Tabaeian, Seidamir Pasha
Khoshbayan, Amin
Shariati, Aref
author_sort Chegini, Zahra
collection PubMed
description BACKGROUND: Hepatic Actinomycosis (HA) is one of the infections that causes disorders in patients when diagnosed untimely and inappropriately. METHODS: Case reports on HA in patients published between 2000 and April 2020 were gathered by carrying out a structured search through PubMed/Medline. RESULTS: Through a survey of the Medline database, 130 studies were identified and then, 64 cases with HA were included in the final analysis. Asia had the largest share of cases with 37.5% (24 reports), followed by Europe and the Americas. Affected patients were predominantly males (64%) and the overall mortality rate was 1% with only one male patient in his 50 s dying. Nearly all patients (92%) were immunocompetent. However, in four patients, the use of immunosuppressive medication led to depression of the immune system. Most of the patients (80%) experienced complications. In terms of the complications, the most frequent ones were previous history of abdominal surgery (32%) and foreign bodies in the abdominopelvic region (20%). Actinomyces israelii was the most common pathogen isolated from patients. Abdominal pain (66%), fever (62%), weight loss (48%), night sweat, malaise, and anorexia (14%) over about 3.1 months were the most frequently reported clinical symptoms. Extension to one or more surrounding organs was evident in 18 patients (28%). Histopathologic examination confirmed infection in 67% of the patients and samples obtained from liver puncture biopsy (32%) were most frequently used in diagnosis. Surgery or puncture drainage + anti-infection was the most common method to treat patients and penicillin, Amoxicillin, Doxycycline, and ampicillin were the most frequently used drugs to control infection. CONCLUSION: HA should be considered in patients with a subacute or chronic inflammatory process of the liver. With accurate and timely diagnosis of infection, extensive surgery can be prevented. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13023-021-01821-5.
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spelling pubmed-80863042021-04-30 A systematic review of case reports of hepatic actinomycosis Chegini, Zahra Didehdar, Mojtaba Tabaeian, Seidamir Pasha Khoshbayan, Amin Shariati, Aref Orphanet J Rare Dis Review BACKGROUND: Hepatic Actinomycosis (HA) is one of the infections that causes disorders in patients when diagnosed untimely and inappropriately. METHODS: Case reports on HA in patients published between 2000 and April 2020 were gathered by carrying out a structured search through PubMed/Medline. RESULTS: Through a survey of the Medline database, 130 studies were identified and then, 64 cases with HA were included in the final analysis. Asia had the largest share of cases with 37.5% (24 reports), followed by Europe and the Americas. Affected patients were predominantly males (64%) and the overall mortality rate was 1% with only one male patient in his 50 s dying. Nearly all patients (92%) were immunocompetent. However, in four patients, the use of immunosuppressive medication led to depression of the immune system. Most of the patients (80%) experienced complications. In terms of the complications, the most frequent ones were previous history of abdominal surgery (32%) and foreign bodies in the abdominopelvic region (20%). Actinomyces israelii was the most common pathogen isolated from patients. Abdominal pain (66%), fever (62%), weight loss (48%), night sweat, malaise, and anorexia (14%) over about 3.1 months were the most frequently reported clinical symptoms. Extension to one or more surrounding organs was evident in 18 patients (28%). Histopathologic examination confirmed infection in 67% of the patients and samples obtained from liver puncture biopsy (32%) were most frequently used in diagnosis. Surgery or puncture drainage + anti-infection was the most common method to treat patients and penicillin, Amoxicillin, Doxycycline, and ampicillin were the most frequently used drugs to control infection. CONCLUSION: HA should be considered in patients with a subacute or chronic inflammatory process of the liver. With accurate and timely diagnosis of infection, extensive surgery can be prevented. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13023-021-01821-5. BioMed Central 2021-04-30 /pmc/articles/PMC8086304/ /pubmed/33931097 http://dx.doi.org/10.1186/s13023-021-01821-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Chegini, Zahra
Didehdar, Mojtaba
Tabaeian, Seidamir Pasha
Khoshbayan, Amin
Shariati, Aref
A systematic review of case reports of hepatic actinomycosis
title A systematic review of case reports of hepatic actinomycosis
title_full A systematic review of case reports of hepatic actinomycosis
title_fullStr A systematic review of case reports of hepatic actinomycosis
title_full_unstemmed A systematic review of case reports of hepatic actinomycosis
title_short A systematic review of case reports of hepatic actinomycosis
title_sort systematic review of case reports of hepatic actinomycosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086304/
https://www.ncbi.nlm.nih.gov/pubmed/33931097
http://dx.doi.org/10.1186/s13023-021-01821-5
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