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Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases

The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several hu...

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Autores principales: Zhi, Yiqiang, Zhou, Xiaokun, Yu, Jurui, Yuan, Ling, Zhang, Hongsheng, Ng, Dominic C. H., Xu, Zhiheng, Xu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086514/
https://www.ncbi.nlm.nih.gov/pubmed/33937237
http://dx.doi.org/10.3389/fcell.2021.640753
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author Zhi, Yiqiang
Zhou, Xiaokun
Yu, Jurui
Yuan, Ling
Zhang, Hongsheng
Ng, Dominic C. H.
Xu, Zhiheng
Xu, Dan
author_facet Zhi, Yiqiang
Zhou, Xiaokun
Yu, Jurui
Yuan, Ling
Zhang, Hongsheng
Ng, Dominic C. H.
Xu, Zhiheng
Xu, Dan
author_sort Zhi, Yiqiang
collection PubMed
description The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several human diseases including neurological disorders, infertility, and tumorigenesis. Recent studies revealed that WDR62 regulates the process of neural stem cell mitosis and germ cell meiosis through JNK signaling. In this review we summarize the roles of WDR62 and JNK signaling in neuronal and non-neuronal contexts and discuss how JNK-dependent signaling regulates both processes. WDR62 is involved in various human disorders via JNK signaling regulation, and may represent a promising therapeutic strategy for the treatment of related diseases.
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spelling pubmed-80865142021-05-01 Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases Zhi, Yiqiang Zhou, Xiaokun Yu, Jurui Yuan, Ling Zhang, Hongsheng Ng, Dominic C. H. Xu, Zhiheng Xu, Dan Front Cell Dev Biol Cell and Developmental Biology The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several human diseases including neurological disorders, infertility, and tumorigenesis. Recent studies revealed that WDR62 regulates the process of neural stem cell mitosis and germ cell meiosis through JNK signaling. In this review we summarize the roles of WDR62 and JNK signaling in neuronal and non-neuronal contexts and discuss how JNK-dependent signaling regulates both processes. WDR62 is involved in various human disorders via JNK signaling regulation, and may represent a promising therapeutic strategy for the treatment of related diseases. Frontiers Media S.A. 2021-04-16 /pmc/articles/PMC8086514/ /pubmed/33937237 http://dx.doi.org/10.3389/fcell.2021.640753 Text en Copyright © 2021 Zhi, Zhou, Yu, Yuan, Zhang, Ng, Xu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhi, Yiqiang
Zhou, Xiaokun
Yu, Jurui
Yuan, Ling
Zhang, Hongsheng
Ng, Dominic C. H.
Xu, Zhiheng
Xu, Dan
Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
title Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
title_full Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
title_fullStr Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
title_full_unstemmed Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
title_short Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
title_sort pathophysiological significance of wdr62 and jnk signaling in human diseases
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086514/
https://www.ncbi.nlm.nih.gov/pubmed/33937237
http://dx.doi.org/10.3389/fcell.2021.640753
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