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Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases
The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several hu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086514/ https://www.ncbi.nlm.nih.gov/pubmed/33937237 http://dx.doi.org/10.3389/fcell.2021.640753 |
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author | Zhi, Yiqiang Zhou, Xiaokun Yu, Jurui Yuan, Ling Zhang, Hongsheng Ng, Dominic C. H. Xu, Zhiheng Xu, Dan |
author_facet | Zhi, Yiqiang Zhou, Xiaokun Yu, Jurui Yuan, Ling Zhang, Hongsheng Ng, Dominic C. H. Xu, Zhiheng Xu, Dan |
author_sort | Zhi, Yiqiang |
collection | PubMed |
description | The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several human diseases including neurological disorders, infertility, and tumorigenesis. Recent studies revealed that WDR62 regulates the process of neural stem cell mitosis and germ cell meiosis through JNK signaling. In this review we summarize the roles of WDR62 and JNK signaling in neuronal and non-neuronal contexts and discuss how JNK-dependent signaling regulates both processes. WDR62 is involved in various human disorders via JNK signaling regulation, and may represent a promising therapeutic strategy for the treatment of related diseases. |
format | Online Article Text |
id | pubmed-8086514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80865142021-05-01 Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases Zhi, Yiqiang Zhou, Xiaokun Yu, Jurui Yuan, Ling Zhang, Hongsheng Ng, Dominic C. H. Xu, Zhiheng Xu, Dan Front Cell Dev Biol Cell and Developmental Biology The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several human diseases including neurological disorders, infertility, and tumorigenesis. Recent studies revealed that WDR62 regulates the process of neural stem cell mitosis and germ cell meiosis through JNK signaling. In this review we summarize the roles of WDR62 and JNK signaling in neuronal and non-neuronal contexts and discuss how JNK-dependent signaling regulates both processes. WDR62 is involved in various human disorders via JNK signaling regulation, and may represent a promising therapeutic strategy for the treatment of related diseases. Frontiers Media S.A. 2021-04-16 /pmc/articles/PMC8086514/ /pubmed/33937237 http://dx.doi.org/10.3389/fcell.2021.640753 Text en Copyright © 2021 Zhi, Zhou, Yu, Yuan, Zhang, Ng, Xu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhi, Yiqiang Zhou, Xiaokun Yu, Jurui Yuan, Ling Zhang, Hongsheng Ng, Dominic C. H. Xu, Zhiheng Xu, Dan Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases |
title | Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases |
title_full | Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases |
title_fullStr | Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases |
title_full_unstemmed | Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases |
title_short | Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases |
title_sort | pathophysiological significance of wdr62 and jnk signaling in human diseases |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086514/ https://www.ncbi.nlm.nih.gov/pubmed/33937237 http://dx.doi.org/10.3389/fcell.2021.640753 |
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