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Modelling the impact of household size distribution on the transmission dynamics of COVID-19

Under the implementation of non-pharmaceutical interventions such as social distancing and lockdowns, household transmission has been shown to be significant for COVID-19, posing challenges for reducing incidence in settings where people are asked to self-isolate at home and to spend increasing amou...

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Detalles Bibliográficos
Autores principales: Liu, Pengyu, McQuarrie, Lisa, Song, Yexuan, Colijn, Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086889/
https://www.ncbi.nlm.nih.gov/pubmed/33906389
http://dx.doi.org/10.1098/rsif.2021.0036
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author Liu, Pengyu
McQuarrie, Lisa
Song, Yexuan
Colijn, Caroline
author_facet Liu, Pengyu
McQuarrie, Lisa
Song, Yexuan
Colijn, Caroline
author_sort Liu, Pengyu
collection PubMed
description Under the implementation of non-pharmaceutical interventions such as social distancing and lockdowns, household transmission has been shown to be significant for COVID-19, posing challenges for reducing incidence in settings where people are asked to self-isolate at home and to spend increasing amounts of time at home due to distancing measures. Accordingly, characteristics of households in a region have been shown to relate to transmission heterogeneity of the virus. We introduce a discrete-time stochastic epidemiological model to examine the impact of the household size distribution in a region on the transmission dynamics. We choose parameters to reflect incidence in two health regions of the Greater Vancouver area in British Columbia and simulate the impact of distancing measures on transmission, with household size distribution the only different parameter between simulations for the two regions. Our result suggests that the dissimilarity in household size distribution alone can cause significant differences in incidence of the two regions, and the distributions drive distinct dynamics that match reported cases. Furthermore, our model suggests that offering individuals a place to isolate outside their household can speed the decline in cases, and does so more effectively where there are more larger households.
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spelling pubmed-80868892021-05-21 Modelling the impact of household size distribution on the transmission dynamics of COVID-19 Liu, Pengyu McQuarrie, Lisa Song, Yexuan Colijn, Caroline J R Soc Interface Life Sciences–Mathematics interface Under the implementation of non-pharmaceutical interventions such as social distancing and lockdowns, household transmission has been shown to be significant for COVID-19, posing challenges for reducing incidence in settings where people are asked to self-isolate at home and to spend increasing amounts of time at home due to distancing measures. Accordingly, characteristics of households in a region have been shown to relate to transmission heterogeneity of the virus. We introduce a discrete-time stochastic epidemiological model to examine the impact of the household size distribution in a region on the transmission dynamics. We choose parameters to reflect incidence in two health regions of the Greater Vancouver area in British Columbia and simulate the impact of distancing measures on transmission, with household size distribution the only different parameter between simulations for the two regions. Our result suggests that the dissimilarity in household size distribution alone can cause significant differences in incidence of the two regions, and the distributions drive distinct dynamics that match reported cases. Furthermore, our model suggests that offering individuals a place to isolate outside their household can speed the decline in cases, and does so more effectively where there are more larger households. The Royal Society 2021-04-28 /pmc/articles/PMC8086889/ /pubmed/33906389 http://dx.doi.org/10.1098/rsif.2021.0036 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Mathematics interface
Liu, Pengyu
McQuarrie, Lisa
Song, Yexuan
Colijn, Caroline
Modelling the impact of household size distribution on the transmission dynamics of COVID-19
title Modelling the impact of household size distribution on the transmission dynamics of COVID-19
title_full Modelling the impact of household size distribution on the transmission dynamics of COVID-19
title_fullStr Modelling the impact of household size distribution on the transmission dynamics of COVID-19
title_full_unstemmed Modelling the impact of household size distribution on the transmission dynamics of COVID-19
title_short Modelling the impact of household size distribution on the transmission dynamics of COVID-19
title_sort modelling the impact of household size distribution on the transmission dynamics of covid-19
topic Life Sciences–Mathematics interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086889/
https://www.ncbi.nlm.nih.gov/pubmed/33906389
http://dx.doi.org/10.1098/rsif.2021.0036
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