IFITM3 functions as PIP3-scaffold to amplify PI3K signaling in B-cells

Ifitm3 was previously identified as an endosomal protein that blocks viral infection(1–3). Studying clinical cohorts of B-cell leukemia and lymphoma patients, we identified IFITM3 as a strong predictor of poor outcome. In normal resting B-cells, Ifitm3 was minimally expressed and mainly localized in...

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Detalles Bibliográficos
Autores principales: Lee, Jaewoong, Robinson, Mark E., Ma, Ning, Artadji, Dewan, Ahmed, Mohamed A., Xiao, Gang, Sadras, Teresa, Deb, Gauri, Winchester, Janet, Cosgun, Kadriye Nehir, Geng, Huimin, Chan, Lai N., Kume, Kohei, Miettinen, Teemu P., Zhang, Ye, Nix, Matthew A., Klemm, Lars, Chen, Chun Wei, Chen, Jianjun, Khairnar, Vishal, Wiita, Arun P., Thomas-Tikhonenko, Andrei, Farzan, Michael, Jung, Jae U., Weinstock, David M., Manalis, Scott R., Diamond, Michael S., Vaidehi, Nagarajan, Müschen, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087162/
https://www.ncbi.nlm.nih.gov/pubmed/33149299
http://dx.doi.org/10.1038/s41586-020-2884-6

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