Multi-omics analyses reveal that HIV-1 alters CD4 T cell immunometabolism to fuel virus replication

Human Immunodeficiency Virus type-1 (HIV-1)-infected individuals show metabolic alterations of CD4 T cells through unclear mechanisms with undefined consequences. We analyzed the transcriptome of CD4 T cells from HIV-1 patients and revealed that elevated oxidative phosphorylation (OXPHOS) pathway is...

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Detalles Bibliográficos
Autores principales: Guo, Haitao, Wang, Qi, Ghneim, Khader, Wang, Li, Rampanelli, Elena, Holley-Guthrie, Elizabeth, Cheng, Liang, Garrido, Carolina, Margolis, David M., Eller, Leigh A., Robb, Merlin L., Sekaly, Rafick-Pierre, Chen, Xian, Su, Lishan, Ting, Jenny P.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087183/
https://www.ncbi.nlm.nih.gov/pubmed/33767427
http://dx.doi.org/10.1038/s41590-021-00898-1

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