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Sulfated glycans engage the Ang/Tie pathway to regulate vascular development

The angiopoietin (Ang)/Tie pathway is essential for the proper maturation and remodeling of the vasculature. Despite its importance in disease, the mechanisms that control signal transduction through this pathway are poorly understood. Here, we demonstrate that heparan sulfate glycosaminoglycans (HS...

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Detalles Bibliográficos
Autores principales: Griffin, Matthew E., Sorum, Alexander W., Miller, Gregory M., Goddard, William A., Hsieh-Wilson, Linda C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087285/
https://www.ncbi.nlm.nih.gov/pubmed/33020664
http://dx.doi.org/10.1038/s41589-020-00657-7