Single-cell analysis reveals effective siRNA delivery in brain tumors with microbubble-enhanced ultrasound and cationic nanoparticles

RNA-based therapies offer unique advantages for treating brain tumors. However, tumor penetrance and uptake are hampered by RNA therapeutic size, charge, and need to be “packaged” in large carriers to improve bioavailability. Here, we have examined delivery of siRNA, packaged in 50-nm cationic lipid...

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Detalles Bibliográficos
Autores principales: Guo, Yutong, Lee, Hohyun, Fang, Zhou, Velalopoulou, Anastasia, Kim, Jinhwan, Thomas, Midhun Ben, Liu, Jingbo, Abramowitz, Ryan G., Kim, YongTae, Coskun, Ahmet F., Krummel, Daniel Pomeranz, Sengupta, Soma, MacDonald, Tobey J., Arvanitis, Costas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087400/
https://www.ncbi.nlm.nih.gov/pubmed/33931452
http://dx.doi.org/10.1126/sciadv.abf7390

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