A highly conserved 3(10) helix within the kinesin motor domain is critical for kinesin function and human health

KIF1A is a critical cargo transport motor within neurons. More than 100 known mutations result in KIF1A-associated neurological disorder (KAND), a degenerative condition for which there is no cure. A missense mutation, P305L, was identified in children diagnosed with KAND, but the molecular basis fo...

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Detalles Bibliográficos
Autores principales: Lam, Aileen J., Rao, Lu, Anazawa, Yuzu, Okada, Kyoko, Chiba, Kyoko, Dacy, Mariah, Niwa, Shinsuke, Gennerich, Arne, Nowakowski, Dan W., McKenney, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087401/
https://www.ncbi.nlm.nih.gov/pubmed/33931448
http://dx.doi.org/10.1126/sciadv.abf1002

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