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Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

The Lon AAA+ protease (LonA) is a ubiquitous ATP-dependent proteolytic machine, which selectively degrades damaged proteins or native proteins carrying exposed motifs (degrons). Here we characterize the structural basis for substrate recognition and discrimination by the N-terminal domain (NTD) of L...

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Detalles Bibliográficos
Autores principales:	Tzeng, Shiou-Ru, Tseng, Yin-Chu, Lin, Chien-Chu, Hsu, Chia-Ying, Huang, Shing-Jong, Kuo, Yi-Ting, Chang, Chung-I
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087443/ https://www.ncbi.nlm.nih.gov/pubmed/33929321 http://dx.doi.org/10.7554/eLife.64056

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