Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Apoptosis is characterized by profound morphological changes, but their physiological purpose is unknown. To characterize the role of apoptotic cell contraction, ROCK1 was rendered caspase non-cleavable (ROCK1nc) by mutating aspartate 1113, which revealed that ROCK1 cleavage was necessary for forcef...

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Detalles Bibliográficos
Autores principales: Julian, Linda, Naylor, Gregory, Wickman, Grant R, Rath, Nicola, Castino, Giovanni, Stevenson, David, Bryson, Sheila, Munro, June, McGarry, Lynn, Mullin, Margaret, Rice, Alistair, Del Río Hernández, Armandodel, Olson, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087448/
https://www.ncbi.nlm.nih.gov/pubmed/33871359
http://dx.doi.org/10.7554/eLife.61983

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