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Analysis of conflict of interest policies among organizations producing clinical practice guidelines
BACKGROUND: Conflicts of interest (COI) jeopardize the validity of Clinical Practice Guidelines (CPGs). When the Institute of Medicine promulgated COI policies in 2011, few organizations met these requirements, but it is unknown if organizations have improved their policies since that time. We sough...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087455/ https://www.ncbi.nlm.nih.gov/pubmed/33930893 http://dx.doi.org/10.1371/journal.pone.0249267 |
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author | Brems, J. Henry Davis, Andrea E. Clayton, Ellen Wright |
author_facet | Brems, J. Henry Davis, Andrea E. Clayton, Ellen Wright |
author_sort | Brems, J. Henry |
collection | PubMed |
description | BACKGROUND: Conflicts of interest (COI) jeopardize the validity of Clinical Practice Guidelines (CPGs). When the Institute of Medicine promulgated COI policies in 2011, few organizations met these requirements, but it is unknown if organizations have improved their policies since that time. We sought to evaluate current adherence to IOM standards of COI policies. METHODS AND FINDINGS: We conducted a retrospective document review of COI policies and CPGs from organizations that published five or more CPGs between January 1, 2018 and December 31, 2019. Organizations were identified via CPG databases. COI policies were obtained from an internet search. We collected data on i) the number of organizations that have COI policies specific to CPG development, ii) the number of policies meeting each IOM standard and iii) the number of IOM standards met by each policy. COI disclosures from five CPGs of each organization were assessed for adherence to IOM standards. Among the 46 organizations that published 5 or more CPGs, 36 (78%) had a COI policy. Standard 2.2b (requiring divestment of financial COI) was met least frequently, by 2 of 36 (6%) organizations. Standard 2.1 (requiring disclosure of COI) was met most frequently, by 33 of 36 (92%) organizations. A total of 31 of 36 (86%) organizations met 4 or fewer of the 7 IOM standards. Among the 16 organizations limiting COI to a minority of the CPG panel (standard 2.4c) and the 15 organizations prohibiting COI among chairs or co-chairs (standard 2.4d), 12 (75%) and 10 (67%) organizations violated the respective standard in at least one CPG. The main limitations of our study are the exclusion of organizations producing fewer CPGs and ability to assess only publicly available policies. CONCLUSION: Among organizations producing CPGs, COI policies frequently do not meet IOM standards, and organizations often violate their own policies. These shortcomings may undermine the public trust in and thus the utility of CPGs. CPG-producing organizations should improve their COI policies and their strategies to manage COI to increase the trustworthiness of CPGs. |
format | Online Article Text |
id | pubmed-8087455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-80874552021-05-11 Analysis of conflict of interest policies among organizations producing clinical practice guidelines Brems, J. Henry Davis, Andrea E. Clayton, Ellen Wright PLoS One Research Article BACKGROUND: Conflicts of interest (COI) jeopardize the validity of Clinical Practice Guidelines (CPGs). When the Institute of Medicine promulgated COI policies in 2011, few organizations met these requirements, but it is unknown if organizations have improved their policies since that time. We sought to evaluate current adherence to IOM standards of COI policies. METHODS AND FINDINGS: We conducted a retrospective document review of COI policies and CPGs from organizations that published five or more CPGs between January 1, 2018 and December 31, 2019. Organizations were identified via CPG databases. COI policies were obtained from an internet search. We collected data on i) the number of organizations that have COI policies specific to CPG development, ii) the number of policies meeting each IOM standard and iii) the number of IOM standards met by each policy. COI disclosures from five CPGs of each organization were assessed for adherence to IOM standards. Among the 46 organizations that published 5 or more CPGs, 36 (78%) had a COI policy. Standard 2.2b (requiring divestment of financial COI) was met least frequently, by 2 of 36 (6%) organizations. Standard 2.1 (requiring disclosure of COI) was met most frequently, by 33 of 36 (92%) organizations. A total of 31 of 36 (86%) organizations met 4 or fewer of the 7 IOM standards. Among the 16 organizations limiting COI to a minority of the CPG panel (standard 2.4c) and the 15 organizations prohibiting COI among chairs or co-chairs (standard 2.4d), 12 (75%) and 10 (67%) organizations violated the respective standard in at least one CPG. The main limitations of our study are the exclusion of organizations producing fewer CPGs and ability to assess only publicly available policies. CONCLUSION: Among organizations producing CPGs, COI policies frequently do not meet IOM standards, and organizations often violate their own policies. These shortcomings may undermine the public trust in and thus the utility of CPGs. CPG-producing organizations should improve their COI policies and their strategies to manage COI to increase the trustworthiness of CPGs. Public Library of Science 2021-04-30 /pmc/articles/PMC8087455/ /pubmed/33930893 http://dx.doi.org/10.1371/journal.pone.0249267 Text en © 2021 Brems et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Brems, J. Henry Davis, Andrea E. Clayton, Ellen Wright Analysis of conflict of interest policies among organizations producing clinical practice guidelines |
title | Analysis of conflict of interest policies among organizations producing clinical practice guidelines |
title_full | Analysis of conflict of interest policies among organizations producing clinical practice guidelines |
title_fullStr | Analysis of conflict of interest policies among organizations producing clinical practice guidelines |
title_full_unstemmed | Analysis of conflict of interest policies among organizations producing clinical practice guidelines |
title_short | Analysis of conflict of interest policies among organizations producing clinical practice guidelines |
title_sort | analysis of conflict of interest policies among organizations producing clinical practice guidelines |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087455/ https://www.ncbi.nlm.nih.gov/pubmed/33930893 http://dx.doi.org/10.1371/journal.pone.0249267 |
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