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Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine

Liver disease is a leading cause of global morbidity and mortality, for which inflammation, alcohol use, lipid metabolic disorders, disturbance to bile acid metabolism, and endotoxins are common risk factors. Traditional Chinese Medicine (TCM) with its “holistic approach” is widely used throughout t...

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Autores principales: Wang, Tingshuai, Huang, Shaodong, Wu, Cong, Wang, Na, Zhang, Rongzhen, Wang, Minggang, Mao, Dewen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087485/
https://www.ncbi.nlm.nih.gov/pubmed/33976705
http://dx.doi.org/10.1155/2021/6682581
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author Wang, Tingshuai
Huang, Shaodong
Wu, Cong
Wang, Na
Zhang, Rongzhen
Wang, Minggang
Mao, Dewen
author_facet Wang, Tingshuai
Huang, Shaodong
Wu, Cong
Wang, Na
Zhang, Rongzhen
Wang, Minggang
Mao, Dewen
author_sort Wang, Tingshuai
collection PubMed
description Liver disease is a leading cause of global morbidity and mortality, for which inflammation, alcohol use, lipid metabolic disorders, disturbance to bile acid metabolism, and endotoxins are common risk factors. Traditional Chinese Medicine (TCM) with its “holistic approach” is widely used throughout the world as a complementary, alternative therapy, due to its clinical efficacy and reduced side effects compared with conventional medicines. However, due to a lack of reliable scientific evidence, the role of TCM in the prevention and treatment of liver disease remains unclear. Over recent years, with the rapid development of high-throughput sequencing, 16S rRNA detection, and bioinformatics methodology, it has been gradually recognized that the regulation of intestinal microbiota by TCM can play a substantial role in the treatment of liver disease. To better understand how TCM regulates the intestinal microbiota and suppresses liver disease, we have reviewed and analyzed the results of existing studies and summarized the relationship and risk factors between intestinal microbiota and liver disease. The present review summarizes the related mechanisms by which TCM affects the composition and metabolites of the intestinal microbiome.
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spelling pubmed-80874852021-05-10 Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine Wang, Tingshuai Huang, Shaodong Wu, Cong Wang, Na Zhang, Rongzhen Wang, Minggang Mao, Dewen Evid Based Complement Alternat Med Review Article Liver disease is a leading cause of global morbidity and mortality, for which inflammation, alcohol use, lipid metabolic disorders, disturbance to bile acid metabolism, and endotoxins are common risk factors. Traditional Chinese Medicine (TCM) with its “holistic approach” is widely used throughout the world as a complementary, alternative therapy, due to its clinical efficacy and reduced side effects compared with conventional medicines. However, due to a lack of reliable scientific evidence, the role of TCM in the prevention and treatment of liver disease remains unclear. Over recent years, with the rapid development of high-throughput sequencing, 16S rRNA detection, and bioinformatics methodology, it has been gradually recognized that the regulation of intestinal microbiota by TCM can play a substantial role in the treatment of liver disease. To better understand how TCM regulates the intestinal microbiota and suppresses liver disease, we have reviewed and analyzed the results of existing studies and summarized the relationship and risk factors between intestinal microbiota and liver disease. The present review summarizes the related mechanisms by which TCM affects the composition and metabolites of the intestinal microbiome. Hindawi 2021-04-22 /pmc/articles/PMC8087485/ /pubmed/33976705 http://dx.doi.org/10.1155/2021/6682581 Text en Copyright © 2021 Tingshuai Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Tingshuai
Huang, Shaodong
Wu, Cong
Wang, Na
Zhang, Rongzhen
Wang, Minggang
Mao, Dewen
Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine
title Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine
title_full Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine
title_fullStr Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine
title_full_unstemmed Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine
title_short Intestinal Microbiota and Liver Diseases: Insights into Therapeutic Use of Traditional Chinese Medicine
title_sort intestinal microbiota and liver diseases: insights into therapeutic use of traditional chinese medicine
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087485/
https://www.ncbi.nlm.nih.gov/pubmed/33976705
http://dx.doi.org/10.1155/2021/6682581
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