TP53 germline mutations in the context of families with hereditary breast and ovarian cancer: a clinical challenge

PURPOSE: TP53germline (g) mutations, associated with the Li-Fraumeni syndrome (LFS), have rarely been reported in the context of hereditary breast and ovarian cancer (HBOC). The prevalence and cancer risks in this target group are unknown and counseling remains challenging. Notably an extensive high...

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Detalles Bibliográficos
Autores principales: Grill, Sabine, Ramser, Juliane, Hellebrand, Heide, Pfarr, Nicole, Boxberg, Melanie, Brambs, Christine, Ditsch, Nina, Meindl, Alfons, Groß, Eva, Meitinger, Thomas, Kiechle, Marion, Quante, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Gynecologic Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087555/
https://www.ncbi.nlm.nih.gov/pubmed/33245408
http://dx.doi.org/10.1007/s00404-020-05883-x

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