Cargando…

Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment

Detalles Bibliográficos
Autores principales:	Multhoff, Gabriele, Vaupel, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Research Highlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087677/ https://www.ncbi.nlm.nih.gov/pubmed/33931598 http://dx.doi.org/10.1038/s41392-021-00598-0

Ejemplares similares

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine
por: Vaupel, Peter, et al.
Publicado: (2017)

Commentary: A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
por: Vaupel, Peter, et al.
Publicado: (2016)

Constant regulation for stable CD8 T‐cell functional avidity and its possible implications for cancer immunotherapy
por: Gilfillan, Connie B., et al.
Publicado: (2021)

Regulatory T cell metabolism at the intersection between autoimmune diseases and cancer
por: Kurniawan, Henry, et al.
Publicado: (2020)

Neutrophil-sourced TNF in cancer: deciphering an intricate orchestrator of immunosuppressive communication in the tumor microenvironment
por: Zhao, Xinyuan, et al.
Publicado: (2023)

Mechanisms of induction of regulatory B cells in the tumour microenvironment and their contribution to immunosuppression and pro-tumour responses
por: Flores-Borja, Fabian, et al.
Publicado: (2022)

Radiotherapy and the tumor microenvironment: The “macro” picture
por: Walton, Emma Louise
Publicado: (2017)

In vivo activation of transferred regulatory T cells specific for third‐party exogenous antigen controls GVH disease in mice
por: Martin, Gaëlle H., et al.
Publicado: (2013)

Microglial lactate metabolism as a potential therapeutic target for Alzheimer’s disease
por: Zhao, Yingjun, et al.
Publicado: (2022)

Tumour travel tours – Why circulating cancer cells value company
por: Häfner, Sophia Julia
Publicado: (2020)

Regulatory T cells as a therapeutic approach for inflammatory bowel disease
por: Laukova, Marcela, et al.
Publicado: (2023)

Serial progression of cortical and medullary thymic epithelial microenvironments
por: Alves, Nuno L, et al.
Publicado: (2014)

Metabolic interaction: tumor-derived lactate inhibiting CD8(+) T cell cytotoxicity in a novel route
por: Wang, Ke, et al.
Publicado: (2023)

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors
por: Multhoff, Gabriele, et al.
Publicado: (2012)

An animated landscape representation of CD4(+) T-cell differentiation, variability, and plasticity: Insights into the behavior of populations versus cells
por: Rebhahn, Jonathan A, et al.
Publicado: (2014)

Competition for nutrients or cell intrinsic programming? – Metabolic mechanisms behind the tumor promoting immune microenvironment in cancer
por: Niu, Yuequn, et al.
Publicado: (2021)

Lactate: The Mediator of Metabolism and Immunosuppression
por: Zhang, Yuanyuan, et al.
Publicado: (2022)

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance
por: Multhoff, Gabriele, et al.
Publicado: (2014)

Protective low-avidity anti-tumour CD8+ T cells are selectively attenuated by regulatory T cells
por: Sugiyarto, Gessa, et al.
Publicado: (2020)

Metabolic dynamics instruct CD8(+) T‐cell differentiation and functions
por: Bevilacqua, Alessio, et al.
Publicado: (2022)

Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment
por: Kelleher, D K, et al.
Publicado: (2003)

A Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922
por: Schwab, Melissa, et al.
Publicado: (2022)

Functional and metabolic dichotomy of murine γδ T cell subsets in cancer immunity
por: Lopes, Noëlla, et al.
Publicado: (2020)

Fa(c)t checking: How fatty acids shape metabolism and function of macrophages and dendritic cells
por: Almeida, Luís, et al.
Publicado: (2021)

STING cg16983159 methylation: a key factor for glioblastoma immunosuppression
por: Qiu, Lei, et al.
Publicado: (2022)

Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy
por: Du, Songtao, et al.
Publicado: (2023)

Digitally deconvolving the tumor microenvironment
por: Aran, Dvir, et al.
Publicado: (2016)

A novel “complement–metabolism–inflammasome axis” as a key regulator of immune cell effector function
por: Arbore, Giuseppina, et al.
Publicado: (2016)

Potential mechanisms by which impaired ketogenesis links metabolism to T‐cell dysfunction in patients with severe COVID‐19
por: Wang, Bin, et al.
Publicado: (2022)

T cells at work: How post‐transcriptional mechanisms control T cell homeostasis and activation
por: Jurgens, Anouk P., et al.
Publicado: (2021)

Metabolic engineering, new antibiotics and biofilm viscoelasticity
por: Daniels, Craig, et al.
Publicado: (2010)

Fine-Tuning the Tumour Microenvironment: Current Perspectives on the Mechanisms of Tumour Immunosuppression
por: Armitage, Jesse D., et al.
Publicado: (2021)

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study
por: Kokowski, Konrad, et al.
Publicado: (2019)

Towards a better metabolic engineering reference: the microbial chassis
por: Abram, Kaleb Z., et al.
Publicado: (2018)

Segregating memories: targeting microenvironment of neuronal ensembles
por: Liu, Ying, et al.
Publicado: (2022)

New strategies for cancer immunotherapy: targeting regulatory T cells
por: Finotello, Francesca, et al.
Publicado: (2017)

Gasdermin: a novel therapeutic target for tumour treatment by activating anti-tumour immunity
por: Fu, Caiyun
Publicado: (2020)

Intricacies in the cross talk between metabolic enzymes, RNA, and protein translation
por: Lv, Yuan, et al.
Publicado: (2019)

AMPKα1: A glucose sensor that controls CD8 T-cell memory
por: Rolf, Julia, et al.
Publicado: (2013)

Complexity and plasticity of cardiac cellular composition
por: Lim, Gregory B.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_5o05giqsldbd38chpe24dh2sg9