Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease characterized by death of motor neurons. The etiology and pathogenesis remains elusive despite decades of intensive research. Herein, we report that dysregulated metabolism plays a central role in the SOD1 G93A mouse model mimicking...

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Detalles Bibliográficos
Autores principales: Trabjerg, Michael Sloth, Andersen, Dennis Christian, Huntjens, Pam, Oklinski, Kirsten Egelund, Bolther, Luise, Hald, Jonas Laugård, Baisgaard, Amalie Elton, Mørk, Kasper, Warming, Nikolaj, Kullab, Ulla Bismark, Kroese, Lona John, Pritchard, Colin Eliot Jason, Huijbers, Ivo Johan, Nieland, John Dirk Vestergaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087699/
https://www.ncbi.nlm.nih.gov/pubmed/33931719
http://dx.doi.org/10.1038/s42003-021-02034-z

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