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Tumor suppressive role of mitochondrial sirtuin 4 in induction of G2/M cell cycle arrest and apoptosis in hepatitis B virus-related hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is developed from uncontrolled cell growth after the malignant transformation of hepatocytes. The hepatitis B virus (HBV) X protein (HBx) has shown to induce cell cycle progression and hepatocarcinogenesis. A sub-fraction of HBx is localized in the mitochondria. Sirtui...

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Detalles Bibliográficos
Autores principales:	Huang, Fung-Yu, Wong, Danny Ka-Ho, Seto, Wai-Kay, Mak, Lung-Yi, Cheung, Tan-To, Yuen, Man-Fung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087836/ https://www.ncbi.nlm.nih.gov/pubmed/33931611 http://dx.doi.org/10.1038/s41420-021-00470-8

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