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Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy

BACKGROUND: To investigate alterations in retinal microvasculature in eyes with preclinical diabetic retinopathy (DR) using ultra-wide field swept-source optical coherence tomography angiography (UWF SS OCTA). METHODS: Prospective cross-sectional study. Fifty-five eyes of 30 diabetic patients withou...

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Autores principales: Yang, Jingyuan, Zhang, Bilei, Wang, Erqian, Xia, Song, Chen, Youxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088031/
https://www.ncbi.nlm.nih.gov/pubmed/33933028
http://dx.doi.org/10.1186/s12886-021-01933-3
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author Yang, Jingyuan
Zhang, Bilei
Wang, Erqian
Xia, Song
Chen, Youxin
author_facet Yang, Jingyuan
Zhang, Bilei
Wang, Erqian
Xia, Song
Chen, Youxin
author_sort Yang, Jingyuan
collection PubMed
description BACKGROUND: To investigate alterations in retinal microvasculature in eyes with preclinical diabetic retinopathy (DR) using ultra-wide field swept-source optical coherence tomography angiography (UWF SS OCTA). METHODS: Prospective cross-sectional study. Fifty-five eyes of 30 diabetic patients without clinical retinal signs were included. All subjects underwent OCTA examination with a 12 × 12 mm(2) field of view of 5 visual fixations (1 central fixation and 4 peripheral fixations) to compose a UWF OCTA image. In the UWF images, the central area corresponded to the original central image obtained using central fixation, and the peripheral area was the remaining area. Lesions, including nonperfusion areas (NPAs), microvascular dilation and tortuosity, and neovascularization (NV), were recorded in different areas. Diabetes history was also recorded. RESULTS: Peripheral areas presented significantly more microvascular dilation and tortuosity than central areas (P = 0.024) and more NPAs than central areas, with borderline significance (P = 0.085). The number of lesion types was associated with HbA1c levels in the peripheral and overall areas (all P values < 0.001). CONCLUSIONS: UWF SS OCTA is a promising imaging method for detecting vascular alterations in diabetic eyes without clinical signs to reveal retinal microvascular alterations. These alterations were correlated with systemic conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-021-01933-3.
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spelling pubmed-80880312021-05-03 Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy Yang, Jingyuan Zhang, Bilei Wang, Erqian Xia, Song Chen, Youxin BMC Ophthalmol Research Article BACKGROUND: To investigate alterations in retinal microvasculature in eyes with preclinical diabetic retinopathy (DR) using ultra-wide field swept-source optical coherence tomography angiography (UWF SS OCTA). METHODS: Prospective cross-sectional study. Fifty-five eyes of 30 diabetic patients without clinical retinal signs were included. All subjects underwent OCTA examination with a 12 × 12 mm(2) field of view of 5 visual fixations (1 central fixation and 4 peripheral fixations) to compose a UWF OCTA image. In the UWF images, the central area corresponded to the original central image obtained using central fixation, and the peripheral area was the remaining area. Lesions, including nonperfusion areas (NPAs), microvascular dilation and tortuosity, and neovascularization (NV), were recorded in different areas. Diabetes history was also recorded. RESULTS: Peripheral areas presented significantly more microvascular dilation and tortuosity than central areas (P = 0.024) and more NPAs than central areas, with borderline significance (P = 0.085). The number of lesion types was associated with HbA1c levels in the peripheral and overall areas (all P values < 0.001). CONCLUSIONS: UWF SS OCTA is a promising imaging method for detecting vascular alterations in diabetic eyes without clinical signs to reveal retinal microvascular alterations. These alterations were correlated with systemic conditions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12886-021-01933-3. BioMed Central 2021-05-01 /pmc/articles/PMC8088031/ /pubmed/33933028 http://dx.doi.org/10.1186/s12886-021-01933-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Yang, Jingyuan
Zhang, Bilei
Wang, Erqian
Xia, Song
Chen, Youxin
Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
title Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
title_full Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
title_fullStr Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
title_full_unstemmed Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
title_short Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
title_sort ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088031/
https://www.ncbi.nlm.nih.gov/pubmed/33933028
http://dx.doi.org/10.1186/s12886-021-01933-3
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