Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci

BACKGROUND: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for this are poorly understood. We aimed to identify trans-ethnic an...

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Detalles Bibliográficos
Autores principales: Breeze, Charles E., Batorsky, Anna, Lee, Mi Kyeong, Szeto, Mindy D., Xu, Xiaoguang, McCartney, Daniel L., Jiang, Rong, Patki, Amit, Kramer, Holly J., Eales, James M., Raffield, Laura, Lange, Leslie, Lange, Ethan, Durda, Peter, Liu, Yongmei, Tracy, Russ P., Van Den Berg, David, Evans, Kathryn L., Kraus, William E., Shah, Svati, Tiwari, Hermant K., Hou, Lifang, Whitsel, Eric A., Jiang, Xiao, Charchar, Fadi J., Baccarelli, Andrea A., Rich, Stephen S., Morris, Andrew P., Irvin, Marguerite R., Arnett, Donna K., Hauser, Elizabeth R., Rotter, Jerome I., Correa, Adolfo, Hayward, Caroline, Horvath, Steve, Marioni, Riccardo E., Tomaszewski, Maciej, Beck, Stephan, Berndt, Sonja I., London, Stephanie J., Mychaleckyj, Josyf C., Franceschini, Nora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088054/
https://www.ncbi.nlm.nih.gov/pubmed/33931109
http://dx.doi.org/10.1186/s13073-021-00877-z

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