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Sex differences in the phylum‐level human gut microbiota composition
BACKGROUND: Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088078/ https://www.ncbi.nlm.nih.gov/pubmed/33931023 http://dx.doi.org/10.1186/s12866-021-02198-y |
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author | Koliada, Alexander Moseiko, Vladislav Romanenko, Mariana Lushchak, Oleh Kryzhanovska, Nadiia Guryanov, Vitaly Vaiserman, Alexander |
author_facet | Koliada, Alexander Moseiko, Vladislav Romanenko, Mariana Lushchak, Oleh Kryzhanovska, Nadiia Guryanov, Vitaly Vaiserman, Alexander |
author_sort | Koliada, Alexander |
collection | PubMed |
description | BACKGROUND: Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. RESULTS: Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. CONCLUSIONS: In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-021-02198-y. |
format | Online Article Text |
id | pubmed-8088078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80880782021-05-03 Sex differences in the phylum‐level human gut microbiota composition Koliada, Alexander Moseiko, Vladislav Romanenko, Mariana Lushchak, Oleh Kryzhanovska, Nadiia Guryanov, Vitaly Vaiserman, Alexander BMC Microbiol Research BACKGROUND: Evidence was previously provided for sex-related differences in the human gut microbiota composition, and sex-specific discrepancy in hormonal profiles was proposed as a main determinant of these differences. On the basis of these findings, the assumption was made on the role of microbiota in the sexual dimorphism of human diseases. To date, sex differences in fecal microbiota were demonstrated primarily at lower taxonomic levels, whereas phylum-level differences between sexes were reported in few studies only. In the present population-based cross-sectional research, sex differences in the phylum-level human gut microbiota composition were identified in a large (total n = 2301) sample of relatively healthy individuals from Ukraine. RESULTS: Relative abundances of Firmicutes and Actinobacteria, as determined by qRT-PCR, were found to be significantly increased, while that of Bacteroidetes was significantly decreased in females compared to males. The Firmicutes to Bacteroidetes (F/B) ratio was significantly increased in females compared to males. Females had 31 % higher odds of having F/B ratio more than 1 than males. This trend was evident in all age groups. The difference between sexes was even more pronounced in the elder individuals (50+): in this age group, female participants had 56 % higher odds of having F/B ratio > 1 than the male ones. CONCLUSIONS: In conclusion, sex-specific differences in the phylum-level intestinal microbiota composition were observed in the Ukraine population. The F/B ratio was significantly increased in females compared to males. Further investigation is needed to draw strong conclusions regarding the mechanistic basis for sex-specific differences in the gut microbiota composition and regarding the role of these differences in the initiation and progression of human chronic diseases. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12866-021-02198-y. BioMed Central 2021-04-30 /pmc/articles/PMC8088078/ /pubmed/33931023 http://dx.doi.org/10.1186/s12866-021-02198-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Koliada, Alexander Moseiko, Vladislav Romanenko, Mariana Lushchak, Oleh Kryzhanovska, Nadiia Guryanov, Vitaly Vaiserman, Alexander Sex differences in the phylum‐level human gut microbiota composition |
title | Sex differences in the phylum‐level human gut microbiota composition |
title_full | Sex differences in the phylum‐level human gut microbiota composition |
title_fullStr | Sex differences in the phylum‐level human gut microbiota composition |
title_full_unstemmed | Sex differences in the phylum‐level human gut microbiota composition |
title_short | Sex differences in the phylum‐level human gut microbiota composition |
title_sort | sex differences in the phylum‐level human gut microbiota composition |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088078/ https://www.ncbi.nlm.nih.gov/pubmed/33931023 http://dx.doi.org/10.1186/s12866-021-02198-y |
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