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Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients

PURPOSE: We aimed to investigate the reactivity of retinal vessels to a flickering stimulus in patients with age-related macular degeneration (AMD) and healthy participants. We also assessed whether the parameters of retinal vessels are dependent on genetic predisposition. METHODS: A total of 354 pa...

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Autores principales: Krytkowska, Elżbieta, Ulańczyk, Zofia, Grabowicz, Aleksandra, Mozolewska-Piotrowska, Katarzyna, Safranow, Krzysztof, Pałucha, Andrzej, Krawczyk, Mariusz, Sikora, Piotr, Matczyńska, Ewa, Stahl, Andreas, Machaliński, Bogusław, Machalińska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088223/
https://www.ncbi.nlm.nih.gov/pubmed/33900362
http://dx.doi.org/10.1167/iovs.62.4.30
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author Krytkowska, Elżbieta
Ulańczyk, Zofia
Grabowicz, Aleksandra
Mozolewska-Piotrowska, Katarzyna
Safranow, Krzysztof
Pałucha, Andrzej
Krawczyk, Mariusz
Sikora, Piotr
Matczyńska, Ewa
Stahl, Andreas
Machaliński, Bogusław
Machalińska, Anna
author_facet Krytkowska, Elżbieta
Ulańczyk, Zofia
Grabowicz, Aleksandra
Mozolewska-Piotrowska, Katarzyna
Safranow, Krzysztof
Pałucha, Andrzej
Krawczyk, Mariusz
Sikora, Piotr
Matczyńska, Ewa
Stahl, Andreas
Machaliński, Bogusław
Machalińska, Anna
author_sort Krytkowska, Elżbieta
collection PubMed
description PURPOSE: We aimed to investigate the reactivity of retinal vessels to a flickering stimulus in patients with age-related macular degeneration (AMD) and healthy participants. We also assessed whether the parameters of retinal vessels are dependent on genetic predisposition. METHODS: A total of 354 patients with AMD and 121 controls were recruited for the study. All participants underwent thorough ophthalmologic examination and static and dynamic retinal vessel analysis. AMD risk polymorphisms were genotyped in the CFH and ARMS2 genes. RESULTS: We found no differences between the AMD group and controls in central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), arteriovenous ratio (AVR), dynamic analysis of arteries (DAAs), or dynamic analysis of veins (DAVs). Eyes with early AMD presented with significantly higher AVR values than eyes with late AMD. In the AMD group, DAA correlated positively with both choroidal thickness (Rs = 0.14, P = 0.00096) and choroidal volume (Rs = 0.23, P < 0.0001), and no such associations were observed in the controls. We found significantly lower DAA (1.47 ± 1.50) in TT homozygotes for the ARMS2 A69S polymorphism in comparison with GG homozygotes (2.38 ± 1.79) and patients with GG + GT genotypes (2.28 ± 1.84). We also observed less prominent DAV (3.24 ± 1.71) in patients with TC + CC genotypes in the CFH Y402H polymorphism compared with TT homozygotes (3.83 ± 1.68). CONCLUSIONS: Our findings suggest that retinal microcirculation appears to be associated with the genetic background, choroidal parameters, and clinical features of the patients with AMD.
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spelling pubmed-80882232021-05-05 Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients Krytkowska, Elżbieta Ulańczyk, Zofia Grabowicz, Aleksandra Mozolewska-Piotrowska, Katarzyna Safranow, Krzysztof Pałucha, Andrzej Krawczyk, Mariusz Sikora, Piotr Matczyńska, Ewa Stahl, Andreas Machaliński, Bogusław Machalińska, Anna Invest Ophthalmol Vis Sci Retina PURPOSE: We aimed to investigate the reactivity of retinal vessels to a flickering stimulus in patients with age-related macular degeneration (AMD) and healthy participants. We also assessed whether the parameters of retinal vessels are dependent on genetic predisposition. METHODS: A total of 354 patients with AMD and 121 controls were recruited for the study. All participants underwent thorough ophthalmologic examination and static and dynamic retinal vessel analysis. AMD risk polymorphisms were genotyped in the CFH and ARMS2 genes. RESULTS: We found no differences between the AMD group and controls in central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE), arteriovenous ratio (AVR), dynamic analysis of arteries (DAAs), or dynamic analysis of veins (DAVs). Eyes with early AMD presented with significantly higher AVR values than eyes with late AMD. In the AMD group, DAA correlated positively with both choroidal thickness (Rs = 0.14, P = 0.00096) and choroidal volume (Rs = 0.23, P < 0.0001), and no such associations were observed in the controls. We found significantly lower DAA (1.47 ± 1.50) in TT homozygotes for the ARMS2 A69S polymorphism in comparison with GG homozygotes (2.38 ± 1.79) and patients with GG + GT genotypes (2.28 ± 1.84). We also observed less prominent DAV (3.24 ± 1.71) in patients with TC + CC genotypes in the CFH Y402H polymorphism compared with TT homozygotes (3.83 ± 1.68). CONCLUSIONS: Our findings suggest that retinal microcirculation appears to be associated with the genetic background, choroidal parameters, and clinical features of the patients with AMD. The Association for Research in Vision and Ophthalmology 2021-04-26 /pmc/articles/PMC8088223/ /pubmed/33900362 http://dx.doi.org/10.1167/iovs.62.4.30 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Retina
Krytkowska, Elżbieta
Ulańczyk, Zofia
Grabowicz, Aleksandra
Mozolewska-Piotrowska, Katarzyna
Safranow, Krzysztof
Pałucha, Andrzej
Krawczyk, Mariusz
Sikora, Piotr
Matczyńska, Ewa
Stahl, Andreas
Machaliński, Bogusław
Machalińska, Anna
Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients
title Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients
title_full Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients
title_fullStr Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients
title_full_unstemmed Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients
title_short Retinal Vessel Functionality Is Linked With ARMS2 A69S and CFH Y402H Polymorphisms and Choroidal Status in AMD Patients
title_sort retinal vessel functionality is linked with arms2 a69s and cfh y402h polymorphisms and choroidal status in amd patients
topic Retina
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088223/
https://www.ncbi.nlm.nih.gov/pubmed/33900362
http://dx.doi.org/10.1167/iovs.62.4.30
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