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SMARCB1-deficient sinonasal carcinoma: a case report and literature review

SWItch/Sucrose Non-Fermentable (SWI/SNF) -related matrix-associated actin-dependent regulator of chromatin (SMARC) subfamily B member 1 (SMARCB1) deficient sinonasal carcinoma (SdSNC) is a rare variant of sinonasal undifferentiated carcinoma (SNUC). A 72-year-old man was referred to our hospital wit...

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Autores principales: Yanagawa, Naoki, Suzuki, Masamichi, Sugimoto, Ryo, Osakabe, Mitsumasa, Uesugi, Noriyuki, Shiga, Kiyoto, Sugai, Tamotsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088288/
https://www.ncbi.nlm.nih.gov/pubmed/33959255
http://dx.doi.org/10.1093/jscr/rjab161
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author Yanagawa, Naoki
Suzuki, Masamichi
Sugimoto, Ryo
Osakabe, Mitsumasa
Uesugi, Noriyuki
Shiga, Kiyoto
Sugai, Tamotsu
author_facet Yanagawa, Naoki
Suzuki, Masamichi
Sugimoto, Ryo
Osakabe, Mitsumasa
Uesugi, Noriyuki
Shiga, Kiyoto
Sugai, Tamotsu
author_sort Yanagawa, Naoki
collection PubMed
description SWItch/Sucrose Non-Fermentable (SWI/SNF) -related matrix-associated actin-dependent regulator of chromatin (SMARC) subfamily B member 1 (SMARCB1) deficient sinonasal carcinoma (SdSNC) is a rare variant of sinonasal undifferentiated carcinoma (SNUC). A 72-year-old man was referred to our hospital with complaints of left facial pain and nasal obstruction. Computed tomography (CI) revealed a tumor 5.5 cm in size in the left nasal cavity. Atypical cells with eosinophilic cytoplasm proliferating as solid nests and exhibiting necrosis were observed and diagnosed as poorly differentiated carcinoma. Carbon ion radiotherapy was performed. Follow-up CI revealed multiple masses in both lungs. Partial resection of the right lung was performed. Proliferating atypical cells with clear-to-eosinophilic cytoplasm were observed and resembled those in the paranasal sinus tumor. Immunohistochemical analysis indicated a metastatic lung tumor derived from the SNUC revealed completely negative SMARCB1 expression in the nuclei of the tumor cells. SdSNC is difficult to diagnose. However, molecular targeted therapy may be useful. Thus, it is necessary and important to recognize this rare cancer accurately.
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spelling pubmed-80882882021-05-05 SMARCB1-deficient sinonasal carcinoma: a case report and literature review Yanagawa, Naoki Suzuki, Masamichi Sugimoto, Ryo Osakabe, Mitsumasa Uesugi, Noriyuki Shiga, Kiyoto Sugai, Tamotsu J Surg Case Rep Case Report SWItch/Sucrose Non-Fermentable (SWI/SNF) -related matrix-associated actin-dependent regulator of chromatin (SMARC) subfamily B member 1 (SMARCB1) deficient sinonasal carcinoma (SdSNC) is a rare variant of sinonasal undifferentiated carcinoma (SNUC). A 72-year-old man was referred to our hospital with complaints of left facial pain and nasal obstruction. Computed tomography (CI) revealed a tumor 5.5 cm in size in the left nasal cavity. Atypical cells with eosinophilic cytoplasm proliferating as solid nests and exhibiting necrosis were observed and diagnosed as poorly differentiated carcinoma. Carbon ion radiotherapy was performed. Follow-up CI revealed multiple masses in both lungs. Partial resection of the right lung was performed. Proliferating atypical cells with clear-to-eosinophilic cytoplasm were observed and resembled those in the paranasal sinus tumor. Immunohistochemical analysis indicated a metastatic lung tumor derived from the SNUC revealed completely negative SMARCB1 expression in the nuclei of the tumor cells. SdSNC is difficult to diagnose. However, molecular targeted therapy may be useful. Thus, it is necessary and important to recognize this rare cancer accurately. Oxford University Press 2021-04-30 /pmc/articles/PMC8088288/ /pubmed/33959255 http://dx.doi.org/10.1093/jscr/rjab161 Text en Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2021. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yanagawa, Naoki
Suzuki, Masamichi
Sugimoto, Ryo
Osakabe, Mitsumasa
Uesugi, Noriyuki
Shiga, Kiyoto
Sugai, Tamotsu
SMARCB1-deficient sinonasal carcinoma: a case report and literature review
title SMARCB1-deficient sinonasal carcinoma: a case report and literature review
title_full SMARCB1-deficient sinonasal carcinoma: a case report and literature review
title_fullStr SMARCB1-deficient sinonasal carcinoma: a case report and literature review
title_full_unstemmed SMARCB1-deficient sinonasal carcinoma: a case report and literature review
title_short SMARCB1-deficient sinonasal carcinoma: a case report and literature review
title_sort smarcb1-deficient sinonasal carcinoma: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088288/
https://www.ncbi.nlm.nih.gov/pubmed/33959255
http://dx.doi.org/10.1093/jscr/rjab161
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