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Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions

BACKGROUND: The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histologic...

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Autores principales: Seyed Ahadi, Maral, Firooz, Alireza, Rahimi, Hoda, Jafari, Mehrdad, Tehranchinia, Zohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088380/
https://www.ncbi.nlm.nih.gov/pubmed/33981338
http://dx.doi.org/10.1155/2021/6618990
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author Seyed Ahadi, Maral
Firooz, Alireza
Rahimi, Hoda
Jafari, Mehrdad
Tehranchinia, Zohreh
author_facet Seyed Ahadi, Maral
Firooz, Alireza
Rahimi, Hoda
Jafari, Mehrdad
Tehranchinia, Zohreh
author_sort Seyed Ahadi, Maral
collection PubMed
description BACKGROUND: The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histological diagnosis as the gold standard. MATERIALS AND METHODS: In this retrospective study, we assessed all the pathology reports from specimens sent to a university hospital laboratory in 3 consecutive years from March 2008 to March 2010. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios were calculated for clinical diagnosis of malignant skin lesions stratified by their histological subtype. RESULTS: A total 4,123 specimen were evaluated. The sensitivity and specificity for clinical diagnosis of malignancy were 90.48% and 82.85%, respectively, whereas the negative predictive value was shown to be 99.06%. The positive and negative likelihood ratios were 5.23 and 0.11, respectively. CONCLUSION: Pathological assessment of skin lesions remains the cornerstone of skin cancer diagnosis. The high NPV and the relatively low PPV indicate that clinical diagnosis is more efficient in ruling out malignancies rather than diagnosing them.
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spelling pubmed-80883802021-05-11 Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions Seyed Ahadi, Maral Firooz, Alireza Rahimi, Hoda Jafari, Mehrdad Tehranchinia, Zohreh Dermatol Res Pract Research Article BACKGROUND: The increasing incidence of skin cancers in fair-skinned population and its relatively good response to treatment make its accurate diagnosis of great importance. We evaluated the accuracy of clinical diagnosis of malignant skin lesions by comparing the clinical diagnosis with histological diagnosis as the gold standard. MATERIALS AND METHODS: In this retrospective study, we assessed all the pathology reports from specimens sent to a university hospital laboratory in 3 consecutive years from March 2008 to March 2010. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and positive and negative likelihood ratios were calculated for clinical diagnosis of malignant skin lesions stratified by their histological subtype. RESULTS: A total 4,123 specimen were evaluated. The sensitivity and specificity for clinical diagnosis of malignancy were 90.48% and 82.85%, respectively, whereas the negative predictive value was shown to be 99.06%. The positive and negative likelihood ratios were 5.23 and 0.11, respectively. CONCLUSION: Pathological assessment of skin lesions remains the cornerstone of skin cancer diagnosis. The high NPV and the relatively low PPV indicate that clinical diagnosis is more efficient in ruling out malignancies rather than diagnosing them. Hindawi 2021-04-22 /pmc/articles/PMC8088380/ /pubmed/33981338 http://dx.doi.org/10.1155/2021/6618990 Text en Copyright © 2021 Maral Seyed Ahadi et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Seyed Ahadi, Maral
Firooz, Alireza
Rahimi, Hoda
Jafari, Mehrdad
Tehranchinia, Zohreh
Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
title Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
title_full Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
title_fullStr Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
title_full_unstemmed Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
title_short Clinical Diagnosis has a High Negative Predictive Value in Evaluation of Malignant Skin Lesions
title_sort clinical diagnosis has a high negative predictive value in evaluation of malignant skin lesions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088380/
https://www.ncbi.nlm.nih.gov/pubmed/33981338
http://dx.doi.org/10.1155/2021/6618990
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