A redox probe screens MTHFD1 as a determinant of gemcitabine chemoresistance in cholangiocarcinoma

Cholangiocarcinoma (CCA) is a type of solid tumor derived from the bile duct epithelium that features universal gemcitabine resistance. Here, we utilized a gene-encoded ROS biosensor probe (HyPer3 probe) to sort subpopulations with different redox statuses from CCA cells. The isolated HyPer-low subp...

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Detalles Bibliográficos
Autores principales: Pan, Ruogu, Yuan, Zhiqing, Liu, Yingbin, Sun, Xuxu, Wang, Guiyang, Wang, Xiaopen, Qu, Junwen, Wang, Jian, Yang, Jie, Zhao, Yuzheng, Yang, Yi, Li, Kewei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088434/
https://www.ncbi.nlm.nih.gov/pubmed/33934113
http://dx.doi.org/10.1038/s41420-021-00476-2

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