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The outcome of TSHoma from a tertiary care institute in India

BACKGROUND: Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is the rarest functioning pituitary adenoma. METHODS: A retrospective analysis of eight patients of TSHomas to highlight the presentations, diagnostic challenges, and treatment outcomes. RESULTS: Median age at diagnos...

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Detalles Bibliográficos
Autores principales: Dutta, Aditya, Jain, Nimisha, Rai, Ashutosh, Gupta, Rahul, Dhandapani, Sivashanmugam, Bhansali, Anil, Radotra, Bishan Das, Ahuja, Chirag Kamal, Dutta, Pinaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Scientific Scholar 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8088499/
https://www.ncbi.nlm.nih.gov/pubmed/33948331
http://dx.doi.org/10.25259/SNI_877_2020
Descripción
Sumario:BACKGROUND: Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (TSHoma) is the rarest functioning pituitary adenoma. METHODS: A retrospective analysis of eight patients of TSHomas to highlight the presentations, diagnostic challenges, and treatment outcomes. RESULTS: Median age at diagnosis was 42 years, median latency to diagnosis was 2.5 years, and thyrotoxic and compressive symptoms were the most common presenting symptoms. At presentation, three cases were plurihormonal, six cases were on medical treatment including thyroxine, and two cases were incidentally discovered. Imaging revealed macroadenoma in all cases. Seven cases underwent pituitary surgery, after which three achieved remission. Another case entered remission after adjunctive radiotherapy. Thyrotropin (TSH) immunostaining was demonstrated in six out of seven adenomas. CONCLUSION: TSHoma is a rare functioning pituitary tumor with both silent and symptomatic presentations. Diagnosis can be established with biochemical and imaging features, even without dynamic tests.